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Tbio
ZFPM2
Zinc finger protein ZFPM2

Protein Summary
Description
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity). The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407775
  • ENSP00000384179
  • ENSG00000169946

Symbol
  • FOG2
  • ZNF89B
  • DIH3
  • FOG2
  • SRXY9
  • ZNF89B
  • hFOG-2
  • ZC2HC11B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
molecular function
0.91
biological process
0.88
PubMedID
0.84
phenotype
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.38   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.38   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
3
4
98.6
venous thromboembolism
4
3
1
1.1
97
platelet count
6
3
4
3.8
95.9
vascular endothelial growth factor measurement
2
1
2
90.2
birth weight
2
2
3
88.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
98.6
venous thromboembolism
1
1.1
97
platelet count
4
3.8
95.9
vascular endothelial growth factor measurement
2
90.2
birth weight
3
88.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein, FOG family member 2
VGNC:10226
464332
Mouse
MGI:1334444
22762
Rat
Dog
zinc finger protein, FOG family member 2
VGNC:48619
481997
Horse
zinc finger protein, FOG family member 2
VGNC:25224
100063119
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein, FOG family member 2
Mouse
Rat
Dog
zinc finger protein, FOG family member 2
Horse
zinc finger protein, FOG family member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WW38-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (29)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.992
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.968
Data Source: STRINGDB
GATA2
Tbio
Family: TF
Novelty: 0.00153967
Score: 0.963
Data Source: STRINGDB
GATA6
Tbio
Family: TF
Novelty: 0.00267511
Score: 0.962
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.958
Data Source: STRINGDB
GATA5
Tbio
Family: TF
Novelty: 0.00759873
Score: 0.946
Data Source: STRINGDB
ZFPM1
Tbio
Family: TF
Novelty: 0.01061715
Score: 0.916
Data Source: STRINGDB
AMH
Tbio
Novelty: 0.00022501
Score: 0.688
Data Source: STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
Score: 0.636
Data Source: STRINGDB
WT1
Tbio
Family: TF
Novelty: 0.00034353
Score: 0.62
Data Source: STRINGDB
Publication Statistics
PubMed Score  103.38

PubMed score by year
PubTator Score  43.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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