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Tbio
TCTEX1D2
Tctex1 domain-containing protein 2

Protein Summary
Description
Required for proper retrograde ciliary transport. Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. This gene encodes a subunit of the human cytoplasmic dynein-2 complex. Mutations in this gene are associated with short-rib thoracic dysplasia 17 with or without polydactyly. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325318
  • ENSP00000324323
  • ENSG00000213123

Symbol
  • SRTD17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.71
kinase perturbation
0.66
transcription factor perturbation
0.61
tissue sample
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (12)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
GO_Central
Protein-Protein Interactions (107)
1 – 10 of 107
WDR60
Tbio
Novelty: 0.19220529
p_int: 0.999999758
p_ni: 2.42e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
TCTEX1D4
Tbio
Novelty: 0.70588235
p_int: 0.999999614
p_ni: 2.66e-7
p_wrong: 1.2e-7
Score: 0.174
Data Source: BioPlex,STRINGDB
COMMD10
Tdark
Novelty: 0.26481715
p_int: 0.999969364
p_ni: 0.000030561
p_wrong: 7.6e-8
Data Source: BioPlex
ABHD17A
Tbio
Family: Enzyme
Novelty: 0.45893806
p_int: 0.999901751
p_ni: 0.000007206
p_wrong: 0.000091043
Score: 0.545
Data Source: BioPlex,STRINGDB
WDR34
Tbio
Novelty: 0.09255525
p_int: 0.999852596
p_ni: 0.000147404
Score: 0.98
Data Source: BioPlex,STRINGDB
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.23762376
p_int: 0.999783053
p_ni: 0.000212962
p_wrong: 0.000003984
Data Source: BioPlex
VWA2
Tbio
Novelty: 0.06471993
p_int: 0.999193671
p_ni: 0.00004613
p_wrong: 0.0007602
Score: 0.203
Data Source: BioPlex,STRINGDB
DEFB121
Tdark
p_int: 0.999152242
p_ni: 0.000834781
p_wrong: 0.000012977
Score: 0.189
Data Source: BioPlex,STRINGDB
ABHD17B
Tbio
Family: Enzyme
p_int: 0.998646764
p_ni: 0.001345258
p_wrong: 0.000007978
Score: 0.158
Data Source: BioPlex,STRINGDB
CLMN
Tbio
Novelty: 0.05179291
p_int: 0.997577546
p_ni: 1.77e-7
p_wrong: 0.002422277
Score: 0.369
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.70

PubMed score by year
PubTator Score  5.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer