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Tdark
APOBEC4
Putative C->U-editing enzyme APOBEC-4

Protein Summary
Description
Putative C to U editing enzyme whose physiological substrate is not yet known. This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308641
  • ENSP00000310622
  • ENSG00000173627

Symbol
  • C1orf169
  • C1orf169
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
microRNA
0.51
disease
0.46
cell line
0.43
kinase perturbation
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
0
2
97.2
1
1
0
1.4
66.8
1
1
0
1.4
63.7
1
1
0
1.4
63.7
1
1
0
1.4
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
97.2
0
1.4
66.8
0
1.4
63.7
0
1.4
63.7
0
1.4
63.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
714993
Mouse
MGI:1918531
71281
Rat
RGD:1560256
498251
Dog
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
VGNC:37997
610630
Horse
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
VGNC:15419
100051909
Species
Name
OMA
EggNOG
Inparanoid
Macaque
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
Mouse
Rat
Dog
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
Horse
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WW27-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Formation of the Editosome (R-HSA-75094)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of the Editosome
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: C to U Conversion
Name
Explore in Pharos
Explore in Source
Formation of the Editosome
Metabolism of RNA
mRNA Editing
mRNA Editing: C to U Conversion
Protein-Protein Interactions (30)
1 – 10 of 30
APOBEC2
Tbio
Novelty:  0.03447716
Score:  0.99
Data Source:  STRINGDB
APOBEC1
Tbio
Novelty:  0.00622042
Score:  0.987
Data Source:  STRINGDB
APOBEC3C
Tbio
Novelty:  0.00882074
Score:  0.978
Data Source:  STRINGDB
APOBEC3B
Tbio
Novelty:  0.008531
Score:  0.977
Data Source:  STRINGDB
APOBEC3A
Tchem
Novelty:  0.00982993
Score:  0.977
Data Source:  STRINGDB
APOBEC3H
Tbio
Novelty:  0.01600106
Score:  0.977
Data Source:  STRINGDB
A1CF
Tbio
Novelty:  0.04151936
Score:  0.947
Data Source:  STRINGDB
APOBEC3G
Tchem
Novelty:  0.00161191
Score:  0.807
Data Source:  STRINGDB
APOBEC3F
Tbio
Novelty:  0.00603614
Score:  0.804
Data Source:  STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
Score:  0.782
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.74

PubMed score by year
PubTator Score  1.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer