Tdark APOBEC4 Putative C->U-editing enzyme APOBEC-4

Protein Summary

Description

Putative C to U editing enzyme whose physiological substrate is not yet known. This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WW27
• Q8N7F6

Gene Name

• APOBEC4

Ensembl ID

• ENST00000308641
• ENSP00000310622
• ENSG00000173627

Symbol

• C1orf169
• C1orf169

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
microRNA	0.51
disease	0.46
cell line	0.43
kinase perturbation	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.53   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.53   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0