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Tbio
TSEN15
tRNA-splicing endonuclease subunit Sen15

Protein Summary
Description
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492). This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423085
  • ENSP00000402002
  • ENSG00000198860
  • ENST00000645668
  • ENSP00000493902

Symbol
  • C1orf19
  • SEN15
  • PCH2F
  • sen15
  • C1orf19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cell type or tissue
0.83
histone modification site profile
0.8
kinase perturbation
0.71
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
6
4
7
5.3
96.5
BMI-adjusted hip circumference
3
10
10
93.1
BMI-adjusted waist circumference
7
9
18
89
smoking behavior
1
1
2
61
sex hormone-binding globulin measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
5.3
96.5
BMI-adjusted hip circumference
10
93.1
BMI-adjusted waist circumference
18
89
smoking behavior
2
61
sex hormone-binding globulin measurement
1
48.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA splicing endonuclease subunit 15
VGNC:1707
457576
Macaque
tRNA splicing endonuclease subunit 15
717481
Mouse
MGI:1913887
66637
Rat
RGD:1308584
289083
Dog
tRNA splicing endonuclease subunit 15
VGNC:47895
610637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA splicing endonuclease subunit 15
Macaque
tRNA splicing endonuclease subunit 15
Mouse
Rat
Dog
tRNA splicing endonuclease subunit 15
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WW01-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA processing
Reactome
tRNA processing in the nucleus
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA processing
tRNA processing in the nucleus
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (42)
1 – 10 of 42
TSEN2
Tbio
Family:  Enzyme
Novelty:  0.04151213
p_int:  0.9999997
p_ni:  3e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
MINK1
Tchem
Family:  Kinase
Novelty:  0.00505208
p_int:  0.999851786
p_ni:  0.000058409
p_wrong:  0.000089805
Score:  0.209
Data Source:  BioPlex,STRINGDB
RANGRF
Tbio
Family:  Enzyme
Novelty:  0.02750539
p_int:  0.999642205
p_ni:  0.000308197
p_wrong:  0.000049598
Score:  0.189
Data Source:  BioPlex,STRINGDB
TSEN34
Tdark
Family:  Enzyme
Novelty:  0.06726323
p_int:  0.999398625
p_ni:  0.000601375
Score:  0.999
Data Source:  BioPlex,STRINGDB
TSEN54
Tbio
Family:  Enzyme
Novelty:  0.03157812
p_int:  0.999014776
p_ni:  0.000985224
Score:  0.998
Data Source:  BioPlex,STRINGDB
CLP1
Tbio
Family:  Enzyme
Novelty:  0.04643806
p_int:  0.989355415
p_ni:  0.010644585
Score:  0.988
Data Source:  BioPlex,STRINGDB
USP7
Tchem
Family:  Enzyme
Novelty:  0.00412878
p_int:  0.942312883
p_ni:  0.057687117
Data Source:  BioPlex
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.914558365
p_ni:  0.085121342
p_wrong:  0.000320294
Data Source:  BioPlex
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.859909573
p_ni:  0.139845401
p_wrong:  0.000245026
Data Source:  BioPlex
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.827105758
p_ni:  0.172894074
p_wrong:  1.67e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  6.84

PubMed score by year
PubTator Score  4.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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