Tbio KBTBD7 Kelch repeat and BTB domain-containing protein 7

Protein Summary

Description

The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q8WVZ9
• B5TZ86
• Q5T6Y7
• Q8NB99
• Q9H0I6

Gene Name

• KBTBD7

Ensembl ID

• ENST00000379483
• ENSP00000368797
• ENSG00000120696

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
transcription factor perturbation	0.8
histone modification site profile	0.74
transcription factor binding site profile	0.73
tissue	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0