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Tbio
FAR1
Fatty acyl-CoA reductase 1

Protein Summary
Description
Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity). The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354817
  • ENSP00000346874
  • ENSG00000197601

Symbol
  • MLSTD2
  • PFCRD
  • MLSTD2
  • SDR10E1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
virus perturbation
0.92
transcription factor binding site profile
0.83
hub protein
0.79
cellular component
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.37   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.37   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Wax and plasmalogen biosynthesis
Reactome
Wax biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Wax and plasmalogen biosynthesis
Wax biosynthesis
Protein-Protein Interactions (35)
1 – 10 of 35
GNPAT
Tchem
Family: Enzyme
Novelty: 0.0152005
Score: 0.89
Data Source: STRINGDB
AGPS
Tbio
Family: Enzyme
Novelty: 0.00129584
Score: 0.867
Data Source: STRINGDB
PEX7
Tbio
Novelty: 0.02053523
Score: 0.815
Data Source: STRINGDB
FAR2
Tbio
Family: Enzyme
Novelty: 0.06046936
Score: 0.808
Data Source: STRINGDB
CCSER1
Tdark
Novelty: 0.24873891
Score: 0.612
Data Source: STRINGDB
PEX19
Tbio
Novelty: 0.00469515
Score: 0.595
Data Source: STRINGDB
FARSA
Tbio
Family: Enzyme
Novelty: 0.00638285
Score: 0.571
Data Source: STRINGDB
DBI
Tbio
Novelty: 0.00395271
Score: 0.55
Data Source: STRINGDB
CLN3
Tbio
Novelty: 0.00085253
Score: 0.534
Data Source: STRINGDB
OSBPL11
Tbio
Novelty: 0.27756361
Score: 0.534
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.37

PubMed score by year
PubTator Score  18.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer