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Tbio
HNRNPLL
Heterogeneous nuclear ribonucleoprotein L-like

Protein Summary
Description
RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409328
  • ENSP00000386575
  • ENSG00000143889
  • ENST00000409636
  • ENSP00000387088
  • ENST00000410076
  • ENSP00000386695
  • ENST00000449105
  • ENSP00000390625

Symbol
  • HNRPLL
  • SRRF
  • SRRF
  • HNRPLL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
transcription factor
0.81
interacting protein
0.8
gene perturbation
0.74
protein complex
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.99   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.99   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0