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Tdark
BTN2A2
Butyrophilin subfamily 2 member A2

Protein Summary
Description
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352867
  • ENSP00000337117
  • ENSG00000124508
  • ENST00000356709
  • ENSP00000349143
  • ENST00000416795
  • ENSP00000399308
  • ENST00000432533
  • ENSP00000394241
  • ENST00000469230
  • ENSP00000417472
  • ENST00000482536
  • ENSP00000419451

Symbol
  • BT2.2
  • BTF2
  • BTF2
  • BT2.2
  • BTN2.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.98
tissue sample
0.68
cell line
0.62
microRNA
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
BTN2A1
Tbio
Novelty:  0.02259329
p_int:  1
Score:  0.289
Data Source:  BioPlex,STRINGDB
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.998155719
p_ni:  0.001844281
Data Source:  BioPlex
PTCHD3
Tbio
Novelty:  0.00081643
p_int:  0.996806809
p_ni:  0.003193184
p_wrong:  7e-9
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.996320635
p_ni:  0.003679365
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.996127955
p_ni:  0.003872039
p_wrong:  6e-9
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.992641474
p_ni:  0.007358494
p_wrong:  3.2e-8
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.990218601
p_ni:  0.009779294
p_wrong:  0.000002105
Data Source:  BioPlex
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
p_int:  0.989737483
p_ni:  0.010262517
Data Source:  BioPlex
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.989058083
p_ni:  0.010941917
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.988644998
p_ni:  0.011355002
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
10
10
97
3
7
0
1.2
94.1
1
5
0
1.1
91.9
self reported educational attainment
4
4
4
90.7
mathematical ability
3
2
3
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
97
0
1.2
94.1
0
1.1
91.9
self reported educational attainment
4
90.7
mathematical ability
3
89
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
butyrophilin subfamily 2 member A2
VGNC:7165
100611509
Macaque
butyrophilin subfamily 2 member A2
699861
Mouse
MGI:3606486
238555
Rat
RGD:1306973
306957
Pig
butyrophilin subfamily 2 member A2
100626604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
butyrophilin subfamily 2 member A2
Macaque
butyrophilin subfamily 2 member A2
Mouse
Rat
Pig
butyrophilin subfamily 2 member A2
Publication Statistics
PubMed Score 4.75
PubMed score by year
PubTator Score 12.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title