BTN2A2
Butyrophilin subfamily 2 member A2
Protein Summary
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
- ENST00000352867
- ENSP00000337117
- ENSG00000124508
- ENST00000356709
- ENSP00000349143
- ENST00000416795
- ENSP00000399308
- ENST00000432533
- ENSP00000394241
- ENST00000469230
- ENSP00000417472
- ENST00000482536
- ENSP00000419451
- BT2.2
- BTF2
- BTF2
- BT2.2
- BTN2.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
virus perturbation | 0.98 | ||
tissue sample | 0.68 | ||
cell line | 0.62 | ||
microRNA | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.75 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 119 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.75 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 119 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (38)
PTCHD3
Novelty: 0.00081643
p_int: 0.996806809
p_ni: 0.003193184
p_wrong: 7e-9
Data Source: BioPlex
RXFP1
Family: GPCR
Novelty: 0.00580827
p_int: 0.996127955
p_ni: 0.003872039
p_wrong: 6e-9
Data Source: BioPlex
HFE
Novelty: 0.00042077
p_int: 0.992641474
p_ni: 0.007358494
p_wrong: 3.2e-8
Data Source: BioPlex
CHRND
Family: IC
Novelty: 0.0441685
p_int: 0.990218601
p_ni: 0.009779294
p_wrong: 0.000002105
Data Source: BioPlex
ATP1B3
Family: Transporter
Novelty: 0.06773518
p_int: 0.989737483
p_ni: 0.010262517
Data Source: BioPlex
MPPE1
Family: Enzyme
Novelty: 0.16027847
p_int: 0.988644998
p_ni: 0.011355002
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Butyrophilin (BTN) family interactions | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Butyrophilin (BTN) family interactions | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (1)
Components (3)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 10 | 10 | 97 | |||||
3 | 7 | 0 | 1.2 | 94.1 | |||||
1 | 5 | 0 | 1.1 | 91.9 | |||||
self reported educational attainment | 4 | 4 | 4 | 90.7 | |||||
mathematical ability | 3 | 2 | 3 | 89 | |||||
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 10 | 97 | |||||
0 | 1.2 | 94.1 | |||||
0 | 1.1 | 91.9 | |||||
self reported educational attainment | 4 | 90.7 | |||||
mathematical ability | 3 | 89 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | butyrophilin subfamily 2 member A2 | VGNC:7165 | 100611509 | |||||
Macaque | butyrophilin subfamily 2 member A2 | 699861 | ||||||
Mouse | MGI:3606486 | 238555 | ||||||
Rat | RGD:1306973 | 306957 | ||||||
Pig | butyrophilin subfamily 2 member A2 | 100626604 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | butyrophilin subfamily 2 member A2 | |||||
Macaque | butyrophilin subfamily 2 member A2 | |||||
Mouse | ||||||
Rat | ||||||
Pig | butyrophilin subfamily 2 member A2 | |||||
Publication Statistics
PubMed Score 4.75
PubMed score by year
PubTator Score 12.67
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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