Tbio POF1B Protein POF1B

Protein Summary

Description

Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q8WVV4
• A8K2U5
• Q5H9E9
• Q5H9F0
• Q8NG12
• Q9H5Y2
• Q9H738
• Q9H744

Gene Name

• POF1B

Ensembl ID

• ENST00000262753
• ENSP00000262753
• ENSG00000124429
• ENST00000373145
• ENSP00000362238

Symbol

• POF
• POF2B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.8
interacting protein	0.74
microRNA	0.65
PubMedID	0.64
gene perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.17   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.17   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0