Protein Summary
Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development. Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010]
- ENST00000262753
- ENSP00000262753
- ENSG00000124429
- ENST00000373145
- ENSP00000362238
- POF
- POF2B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.8 | ||
interacting protein | 0.74 | ||
microRNA | 0.65 | ||
PubMedID | 0.64 | ||
gene perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.42 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 90 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.42 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 90 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (80)
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.999232344
p_ni: 0.000767656
Data Source: BioPlex
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.994216593
p_ni: 0.005783407
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | POF1B, actin binding protein | VGNC:48890 | 473686 | |||||
Macaque | POF1B, actin binding protein | 694245 | ||||||
Mouse | MGI:1916943 | 69693 | ||||||
Rat | RGD:1560798 | 302328 | ||||||
Dog | POF1B, actin binding protein | VGNC:44766 | 491994 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | POF1B, actin binding protein | |||||
Macaque | POF1B, actin binding protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | POF1B, actin binding protein | |||||
Publication Statistics
PubMed Score 9.42
PubMed score by year
PubTator Score 137.09
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (4)
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