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Tbio
TRAPPC12
Trafficking protein particle complex subunit 12

Protein Summary
Description
Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324266
  • ENSP00000324318
  • ENSG00000171853
  • ENST00000382110
  • ENSP00000371544

Symbol
  • TRAMM
  • TTC15
  • PEBAS
  • TTC15
  • CGI-87
  • TTC-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
histone modification site profile
0.72
drug perturbation
0.71
cell line
0.69
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.79   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.79   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0