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Tbio
TRAPPC12
Trafficking protein particle complex subunit 12

Protein Summary
Description
Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324266
  • ENSP00000324318
  • ENSG00000171853
  • ENST00000382110
  • ENSP00000371544

Symbol
  • TRAMM
  • TTC15
  • PEBAS
  • TTC15
  • CGI-87
  • TTC-15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
histone modification site profile
0.72
drug perturbation
0.71
cell line
0.69
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.45   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.45   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
TPE interval measurement
1
1
1
21.5
response to exercise
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
TPE interval measurement
1
21.5
response to exercise
1
21.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 12
VGNC:400
459000
Macaque
trafficking protein particle complex 12
707758
Mouse
MGI:2445089
217449
Rat
RGD:1566054
314013
Dog
trafficking protein particle complex 12
VGNC:47779
475647
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 12
Macaque
trafficking protein particle complex 12
Mouse
Rat
Dog
trafficking protein particle complex 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WVT3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Protein-Protein Interactions (45)
1 – 10 of 45
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  1
Score:  0.994
Data Source:  BioPlex,STRINGDB
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
TRAPPC13
Tdark
Novelty:  0.4415
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.999999999
p_ni:  1e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
TRAPPC11
Tbio
Novelty:  0.05737444
p_int:  0.999999505
p_ni:  4.95e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
CEP55
Tbio
Novelty:  0.01328073
p_int:  0.999999407
p_ni:  5.93e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
TRAPPC8
Tdark
Novelty:  0.07711264
p_int:  0.999989195
p_ni:  0.000010805
Score:  0.997
Data Source:  BioPlex,STRINGDB
TRAPPC6A
Tbio
Novelty:  0.09865129
p_int:  0.999988145
p_ni:  0.000010184
p_wrong:  0.00000167
Score:  0.993
Data Source:  BioPlex,STRINGDB
TBC1D14
Tbio
Novelty:  0.25089884
p_int:  0.999909303
p_ni:  0.000090696
Score:  0.907
Data Source:  BioPlex,STRINGDB
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.99988102
p_ni:  0.000118887
p_wrong:  9.3e-8
Data Source:  BioPlex
Publication Statistics
PubMed Score  11.45

PubMed score by year
PubTator Score  2.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer