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Tbio
WDR60
WD repeat-containing protein 60

Protein Summary
Description
May play a role in ciliogenesis. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) and may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein contains four WD repeats and may play a role in the formation of cilia. Mutations in this gene have been associated with short-rib polydactyly and Jeune syndromes. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407559
  • ENSP00000384290
  • ENSG00000126870

Symbol
  • SRPS6
  • SRTD8
  • FAP163
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
histone modification site profile
0.65
transcription factor binding site profile
0.65
cellular component
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.09   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.09   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
TCTEX1D2
Tbio
Novelty:  0.15075459
p_int:  0.999999758
p_ni:  2.42e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
TCTEX1D4
Tbio
Novelty:  1.11393549
p_int:  0.999824836
p_ni:  0.000175162
p_wrong:  2e-9
Score:  0.499
Data Source:  BioPlex,STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.977353839
p_ni:  0.022646161
Data Source:  BioPlex
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.974438503
p_ni:  0.025561497
Data Source:  BioPlex
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.971352718
p_ni:  0.028647282
Data Source:  BioPlex
WDFY3
Tbio
Novelty:  0.01670166
p_int:  0.863325091
p_ni:  0.136674574
p_wrong:  3.35e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
TENT5A
Tbio
Novelty:  0.08412895
p_int:  0.850213551
p_ni:  0.149606388
p_wrong:  0.000180061
Score:  0.18
Data Source:  BioPlex,STRINGDB
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.817033107
p_ni:  0.182909342
p_wrong:  0.000057551
Data Source:  BioPlex
DYNLRB2
Tbio
Novelty:  0.1714161
Score:  0.979
Data Source:  STRINGDB
DYNC2H1
Tbio
Novelty:  0.01306616
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
5
5
97.9
platelet count
1
1
1
68.8
1
1
0
1.3
59.5
influenza A (H1N1)
1
1
0
23.2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
97.9
platelet count
1
68.8
0
1.3
59.5
influenza A (H1N1)
0
23.2
21.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 60
705405
Mouse
MGI:2445085
217935
Rat
RGD:1306493
314523
Dog
WD repeat domain 60
VGNC:48379
482827
Horse
WD repeat domain 60
VGNC:25008
100057672
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WD repeat domain 60
Mouse
Rat
Dog
WD repeat domain 60
Horse
WD repeat domain 60
Publication Statistics
PubMed Score 8.09
PubMed score by year
PubTator Score 6.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title