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Tdark
TNFAIP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

Protein Summary
Description
Acts as a negative regulator of mTOR activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327473
  • ENSP00000331827
  • ENSG00000185361
  • ENST00000536716
  • ENSP00000444215

Symbol
  • TIPE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.68
tissue sample
0.62
histone modification site profile
0.58
tissue
0.56
transcription factor perturbation
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 8 like 1
VGNC:13098
468676
Macaque
TNF alpha induced protein 8 like 1
694323
Mouse
MGI:1913693
66443
Rat
RGD:1588574
301131
Dog
TNF alpha induced protein 8 like 1
485034
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 8 like 1
Macaque
TNF alpha induced protein 8 like 1
Mouse
Rat
Dog
TNF alpha induced protein 8 like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WVP5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (18)
1 – 10 of 18
FBXW5
Tbio
Novelty: 0.13100873
Score: 0.819
Data Source: STRINGDB
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
Score: 0.777
Data Source: STRINGDB
PRR16
Tdark
Novelty: 0.17809341
Score: 0.621
Data Source: STRINGDB
SCNM1
Tbio
Novelty: 0.19700548
Score: 0.592
Data Source: STRINGDB
CCNYL1
Tdark
Novelty: 0.45350824
Score: 0.505
Data Source: STRINGDB
RBBP9
Tchem
Family: Enzyme
Novelty: 0.08692052
Score: 0.485
Data Source: STRINGDB
CASP9
Tchem
Family: Enzyme
Novelty: 0.00023687
Score: 0.478
Data Source: STRINGDB
HTATIP2
Tbio
Family: Enzyme
Novelty: 0.01940704
Score: 0.47
Data Source: STRINGDB
C1QTNF5
Tbio
Score: 0.451
Data Source: STRINGDB
SMIM12
Tdark
Novelty: 0.46683938
Score: 0.446
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.56

PubMed score by year
PubTator Score  13.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer