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Tbio
STAG1
Cohesin subunit SA-1

Protein Summary
Description
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236698
  • ENSP00000236698
  • ENSG00000118007
  • ENST00000383202
  • ENSP00000372689

Symbol
  • SA1
  • SCC3
  • SA1
  • MRD47
  • SCC3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
interacting protein
0.97
kinase perturbation
0.95
transcription factor perturbation
0.91
transcription factor
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.16   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1242.16   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (228)
RAD21
Tbio
Novelty:  0.00270936
p_int:  0.999999994
p_ni:  6e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.999755219
p_ni:  0.000244781
Data Source:  BioPlex
GPR183
Tchem
Family:  GPCR
Novelty:  0.02005679
p_int:  0.999523257
p_ni:  0.000476298
p_wrong:  4.46e-7
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999072183
p_ni:  0.000927816
p_wrong:  1e-9
Data Source:  BioPlex
TRMT13
Tdark
Novelty:  3.91234304
p_int:  0.998637963
p_ni:  0.000494664
p_wrong:  0.000867373
Score:  0.305
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.993501568
p_ni:  0.006498431
p_wrong:  1e-9
Data Source:  BioPlex
CD83
Tbio
Novelty:  0.00138653
p_int:  0.975513224
p_ni:  0.024484726
p_wrong:  0.00000205
Data Source:  BioPlex
KLKB1
Tclin
Family:  Enzyme
Novelty:  0.00109438
p_int:  0.896047127
p_ni:  0.103493023
p_wrong:  0.00045985
Data Source:  BioPlex
TNFSF10
Tchem
Novelty:  0.00096612
p_int:  0.892270823
p_ni:  0.107316194
p_wrong:  0.000412983
Data Source:  BioPlex
PNOC
Tbio
Novelty:  0.00132014
p_int:  0.8834287
p_ni:  0.013078436
p_wrong:  0.103492864
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
ESR-mediated signaling
Reactome
Establishment of Sister Chromatid Cohesion
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
ESR-mediated signaling
Establishment of Sister Chromatid Cohesion
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (70)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
10
5
2
1.1
96.4
high density lipoprotein cholesterol measurement
18
11
18
95.7
triglyceride measurement
24
8
24
95.5
body height
3
3
3
92.4
body mass index
4
2
4
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
2
1.1
96.4
high density lipoprotein cholesterol measurement
18
95.7
triglyceride measurement
24
95.5
body height
3
92.4
body mass index
4
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1098658
20842
Rat
RGD:1310744
315958
Dog
stromal antigen 1
VGNC:46873
485674
Horse
stromal antigen 1
VGNC:49271
100066027
Cow
stromal antigen 1
VGNC:35353
539234
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
stromal antigen 1
Horse
stromal antigen 1
Cow
stromal antigen 1
Publication Statistics
PubMed Score 1242.16
PubMed score by year
PubTator Score 84.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title