Tbio TFB1M Dimethyladenosine transferase 1, mitochondrial

Protein Summary

Description

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• Q8WVM0
• Q05DR0
• Q9Y384

Gene Name

• TFB1M

Ensembl ID

• ENST00000367166
• ENSP00000356134
• ENSG00000029639

Symbol

• CGI75
• mtTFB
• CGI-75
• mtTFB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
protein domain	0.85
transcription factor perturbation	0.74
transcription factor binding site profile	0.71
cell type or tissue	0.69

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Rna Methyltransferase / Dimethyladenosine Transferase 1, Mitochondrial

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Methyltransferase / Dimethyladenosine Transferase 1, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.53   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.53   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0