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Tbio
TFB1M
Dimethyladenosine transferase 1, mitochondrial

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367166
  • ENSP00000356134
  • ENSG00000029639

Symbol
  • CGI75
  • mtTFB
  • CGI-75
  • mtTFB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
protein domain
0.85
transcription factor perturbation
0.74
transcription factor binding site profile
0.71
cell type or tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.44   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.44   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (208)
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.99998806
p_ni:  0.00001194
Score:  0.648
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.999338835
p_ni:  0.000661137
p_wrong:  2.9e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.998572726
p_ni:  0.001427274
Score:  0.463
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.994073693
p_ni:  0.004891149
p_wrong:  0.001035158
Score:  0.365
Data Source:  BioPlex,STRINGDB
DCAF8
Tbio
Novelty:  0.12456534
p_int:  0.993006535
p_ni:  0.006993465
Data Source:  BioPlex
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.990737792
p_ni:  0.009145894
p_wrong:  0.000116314
Score:  0.156
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.990156917
p_ni:  0.009720773
p_wrong:  0.000122309
Score:  0.193
Data Source:  BioPlex,STRINGDB
POLRMT
Tbio
Family:  Enzyme
Novelty:  0.01398067
Score:  0.986
Data Source:  STRINGDB
NRF1
Tbio
Family:  TF
Novelty:  0.00543248
Score:  0.963
Data Source:  STRINGDB
TFAM
Tbio
Family:  TF
Novelty:  0.00131608
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
Transcriptional activation of mitochondrial biogenesis
Reactome
rRNA modification in the mitochondrion
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Transcriptional activation of mitochondrial biogenesis
rRNA modification in the mitochondrion
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
10.4
self reported educational attainment
1
1
1
10.1
cognitive function measurement
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
10.4
self reported educational attainment
1
10.1
cognitive function measurement
1
7.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor B1, mitochondrial
VGNC:12714
737921
Macaque
transcription factor B1, mitochondrial
701830
Mouse
MGI:2146851
224481
Rat
RGD:727795
308140
Dog
transcription factor B1, mitochondrial
VGNC:47288
476253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor B1, mitochondrial
Macaque
transcription factor B1, mitochondrial
Mouse
Rat
Dog
transcription factor B1, mitochondrial
Publication Statistics
PubMed Score 45.44
PubMed score by year
PubTator Score 17.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title