SNRNP27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
Protein Summary
May play a role in mRNA splicing. This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
- ENST00000244227
- ENSP00000244227
- ENSG00000124380
- ENST00000450162
- ENSP00000395144
- 27K
- RY1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.74 | ||
transcription factor perturbation | 0.74 | ||
kinase perturbation | 0.66 | ||
transcription factor binding site profile | 0.65 | ||
histone modification site profile | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.28 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 55 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.28 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 55 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0