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Tbio
UCMA
Unique cartilage matrix-associated protein

Protein Summary
Description
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378681
  • ENSP00000367952
  • ENSG00000165623

Symbol
  • C10orf49
  • GRP
  • C10orf49
  • GRP/UCMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
tissue
0.55
cell line
0.43
cellular component
0.42
tissue sample
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.22   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.22   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (12)
SP7
Tbio
Family:  TF
Novelty:  0.00102606
Score:  0.909
Data Source:  STRINGDB
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
Score:  0.9
Data Source:  STRINGDB
FMOD
Tbio
Novelty:  0.00459438
Score:  0.56
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.549
Data Source:  STRINGDB
PDGFRL
Tbio
Novelty:  0.0709225
Score:  0.547
Data Source:  STRINGDB
LUM
Tbio
Novelty:  0.00219939
Score:  0.511
Data Source:  STRINGDB
EFCAB2
Tdark
Novelty:  0.26420728
Score:  0.485
Data Source:  STRINGDB
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
Score:  0.473
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.458
Data Source:  STRINGDB
ITIH6
Tdark
Novelty:  4.5922884
Score:  0.452
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX2 regulates bone development
Reactome
RUNX2 regulates osteoblast differentiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX2 regulates bone development
RUNX2 regulates osteoblast differentiation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
62.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
upper zone of growth plate and cartilage matrix associated
VGNC:5871
736681
Macaque
upper zone of growth plate and cartilage matrix associated
698795
Mouse
MGI:1915777
68527
Rat
RGD:1308977
291312
Dog
upper zone of growth plate and cartilage matrix associated
VGNC:48107
478002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
upper zone of growth plate and cartilage matrix associated
Macaque
upper zone of growth plate and cartilage matrix associated
Mouse
Rat
Dog
upper zone of growth plate and cartilage matrix associated
Publication Statistics
PubMed Score 9.22
PubMed score by year
PubTator Score 11.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title