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Tbio
UCMA
Unique cartilage matrix-associated protein

Protein Summary
Description
May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378681
  • ENSP00000367952
  • ENSG00000165623

Symbol
  • C10orf49
  • GRP
  • C10orf49
  • GRP/UCMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.63
tissue
0.55
cell line
0.43
cellular component
0.42
tissue sample
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.51   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.51   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX2 regulates bone development
Reactome
RUNX2 regulates osteoblast differentiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX2 regulates bone development
RUNX2 regulates osteoblast differentiation
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (12)
1 – 10 of 12
SP7
Tbio
Family: TF
Novelty: 0.00102606
Score: 0.909
Data Source: STRINGDB
CBFB
Tchem
Family: TF
Novelty: 0.04825679
Score: 0.9
Data Source: STRINGDB
FMOD
Tbio
Novelty: 0.00459438
Score: 0.56
Data Source: STRINGDB
COL11A1
Tbio
Novelty: 0.00594683
Score: 0.549
Data Source: STRINGDB
PDGFRL
Tbio
Novelty: 0.0709225
Score: 0.547
Data Source: STRINGDB
LUM
Tbio
Novelty: 0.00219939
Score: 0.511
Data Source: STRINGDB
EFCAB2
Tdark
Novelty: 0.26420728
Score: 0.485
Data Source: STRINGDB
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
Score: 0.473
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.458
Data Source: STRINGDB
ITIH6
Tdark
Novelty: 4.5922884
Score: 0.452
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.51

PubMed score by year
PubTator Score  11.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer