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Tbio
RNF138
E3 ubiquitin-protein ligase RNF138

Protein Summary
Description
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:1671 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257190
  • ENSP00000257190
  • ENSG00000134758
  • ENST00000261593
  • ENSP00000261593

Symbol
  • NARF
  • NARF
  • HSD-4
  • STRIN
  • hNARF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
protein domain
0.73
transcription factor
0.73
microRNA
0.71
transcription factor binding site profile
0.71


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.73   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.73   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 138
VGNC:9919
455361
Macaque
ring finger protein 138
706926
Mouse
MGI:1929211
56515
Dog
ring finger protein 138
VGNC:45631
480165
Horse
ring finger protein 138
VGNC:22436
100066302
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 138
Macaque
ring finger protein 138
Mouse
Dog
ring finger protein 138
Horse
ring finger protein 138
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WVD3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (299)
1 – 10 of 299
EIF1AD
Tdark
Novelty: 0.23915521
p_int: 0.999410511
p_ni: 0.000589489
Data Source: BioPlex
NAP1L5
Tbio
Novelty: 0.10378595
p_int: 0.999289733
p_ni: 0.000710267
Score: 0.203
Data Source: BioPlex,STRINGDB
BZW1
Tbio
Novelty: 0.11677238
p_int: 0.997585316
p_ni: 0.00241347
p_wrong: 0.000001215
Score: 0.259
Data Source: BioPlex,STRINGDB
NECAB1
Tbio
Novelty: 0.24384799
p_int: 0.994589482
p_ni: 0.005408492
p_wrong: 0.000002026
Score: 0.185
Data Source: BioPlex,STRINGDB
POLE3
Tbio
Family: Enzyme
Novelty: 0.09657513
p_int: 0.99233063
p_ni: 0.007669321
p_wrong: 4.8e-8
Data Source: BioPlex
PHF8
Tchem
Family: Epigenetic
Novelty: 0.01946151
p_int: 0.99068651
p_ni: 0.009313419
p_wrong: 7e-8
Data Source: BioPlex
C16orf71
Tdark
Novelty: 0.97826087
p_int: 0.964352368
p_ni: 0.035647632
Data Source: BioPlex
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.961952383
p_ni: 0.028443997
p_wrong: 0.00960362
Score: 0.906
Data Source: BioPlex,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.959057027
p_ni: 0.04093711
p_wrong: 0.000005863
Data Source: BioPlex
UBE2K
Tbio
Novelty: 0.00214955
p_int: 0.957571666
p_ni: 0.042428334
Score: 0.944
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.73

PubMed score by year
PubTator Score  8.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer