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Tbio
LEO1
RNA polymerase-associated protein LEO1

Protein Summary
Description
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299601
  • ENSP00000299601
  • ENSG00000166477
  • ENST00000315141
  • ENSP00000314610

Symbol
  • RDL
  • RDL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
biological process
0.86
transcription factor binding site profile
0.85
ligand (protein) perturbation
0.83
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Formation of RNA Pol II elongation complex
Reactome
Formation of the beta-catenin:TCF transactivating complex
Reactome
Gene expression (Transcription)
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Formation of RNA Pol II elongation complex
Formation of the beta-catenin:TCF transactivating complex
Gene expression (Transcription)
Metabolism of proteins
Protein-Protein Interactions (237)
1 – 10 of 237
CDC73
Tbio
Novelty: 0.00362973
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PAF1
Tbio
Family: Enzyme
Novelty: 0.00200047
p_int: 0.999999998
p_ni: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty: 0.01125284
p_int: 0.999233457
p_ni: 0.000757476
p_wrong: 0.000009067
Score: 0.266
Data Source: BioPlex,STRINGDB
TULP2
Tdark
Family: TF
Novelty: 0.20144336
p_int: 0.995765129
p_ni: 0.000105212
p_wrong: 0.004129659
Score: 0.741
Data Source: BioPlex,STRINGDB
RTF1
Tbio
Family: Enzyme
Novelty: 0.02255644
Score: 0.999
Data Source: STRINGDB
CTR9
Tbio
Family: Enzyme
Novelty: 0.04434964
Score: 0.999
Data Source: STRINGDB
SUPT16H
Tbio
Family: Enzyme
Novelty: 0.01026868
Score: 0.998
Data Source: STRINGDB
WDR61
Tbio
Novelty: 0.01405991
Score: 0.998
Data Source: STRINGDB
SSRP1
Tbio
Family: TF
Novelty: 0.0143993
Score: 0.998
Data Source: STRINGDB
SUPT5H
Tbio
Novelty: 0.00775042
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  118.56

PubMed score by year
PubTator Score  35.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer