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Tbio
CHTF18
Chromosome transmission fidelity protein 18 homolog

Protein Summary
Description
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during me ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262315
  • ENSP00000262315
  • ENSG00000127586
  • ENST00000455171
  • ENSP00000406252

Symbol
  • C16orf41
  • CTF18
  • CHL12
  • Ctf18
  • RUVBL
  • C16orf41
  • C321D2.2
  • C321D2.3
  • C321D2.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.88
histone modification site profile
0.86
protein complex
0.8
molecular function
0.79
interacting protein
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (187)
RFC4
Tbio
Novelty:  0.03232586
p_int:  0.999999975
p_ni:  2.5e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
JAKMIP1
Tbio
Family:  Enzyme
Novelty:  0.09039444
p_int:  0.999999837
p_ni:  1.32e-7
p_wrong:  3.2e-8
Data Source:  BioPlex
RFC5
Tbio
Novelty:  0.03987481
p_int:  0.999998524
p_ni:  0.000001476
Score:  0.997
Data Source:  BioPlex,STRINGDB
DSCC1
Tbio
Novelty:  0.04747149
p_int:  0.999994746
p_ni:  0.000005254
Score:  0.999
Data Source:  BioPlex,STRINGDB
P0CG12
Tdark
Novelty:  0.15007488
p_int:  0.99772344
p_ni:  0.000211725
p_wrong:  0.002064835
Score:  0.997
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.99766115
p_ni:  0.00233885
Score:  0.205
Data Source:  BioPlex,STRINGDB
PHOSPHO1
Tchem
Family:  Enzyme
Novelty:  0.05458897
p_int:  0.986067349
p_ni:  0.013901349
p_wrong:  0.000031302
Score:  0.513
Data Source:  BioPlex,STRINGDB
ALDOB
Tbio
Family:  Enzyme
Novelty:  0.00856695
p_int:  0.976959403
p_ni:  0.017996158
p_wrong:  0.005044438
Data Source:  BioPlex
DRC3
Tdark
Novelty:  0.99283468
p_int:  0.8101104
p_ni:  0.189886713
p_wrong:  0.000002887
Data Source:  BioPlex
RFC2
Tbio
Novelty:  0.02088405
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
6
90.4
BMI-adjusted waist circumference
1
6
6
82.2
cancer antigen 125 measurement
1
3
3
77.9
mean corpuscular volume
1
1
1
74.6
mean reticulocyte volume
1
1
1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
90.4
BMI-adjusted waist circumference
6
82.2
cancer antigen 125 measurement
3
77.9
mean corpuscular volume
1
74.6
mean reticulocyte volume
1
72.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chromosome transmission fidelity factor 18
698475
Mouse
MGI:2384887
214901
Rat
RGD:1310473
287146
Dog
chromosome transmission fidelity factor 18
VGNC:39260
490084
Horse
chromosome transmission fidelity factor 18
VGNC:51120
100067225
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chromosome transmission fidelity factor 18
Mouse
Rat
Dog
chromosome transmission fidelity factor 18
Horse
chromosome transmission fidelity factor 18
Publication Statistics
PubMed Score 42.94
PubMed score by year
PubTator Score 12.97
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title