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Tbio
HEXD
Hexosaminidase D

Protein Summary
Description
Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327949
  • ENSP00000332634
  • ENSG00000169660
  • ENST00000337014
  • ENSP00000337854
  • ENST00000644009
  • ENSP00000496193

Symbol
  • HEXDC
  • HEXDC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.66
transcription factor binding site profile
0.59
tissue sample
0.58
cellular component
0.55
transcription factor
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.81   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.81   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Various types of N-glycan biosynthesis
KEGG
Other glycan degradation
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Various types of N-glycan biosynthesis
Other glycan degradation
Metabolic pathways
Protein-Protein Interactions (27)
1 – 10 of 27
HEXA
Tchem
Family: Enzyme
Novelty: 0.00302415
Score: 0.94
Data Source: STRINGDB
HEXB
Tchem
Family: Enzyme
Novelty: 0.00792435
Score: 0.919
Data Source: STRINGDB
YPEL5
Tbio
Novelty: 0.35820896
Score: 0.697
Data Source: STRINGDB
OGA
Tchem
Family: Enzyme
Novelty: 0.00040103
Score: 0.672
Data Source: STRINGDB
ZNF662
Tdark
Family: TF
Novelty: 5
Score: 0.602
Data Source: STRINGDB
FAM198A
Tdark
Novelty: 2.66666667
Score: 0.58
Data Source: STRINGDB
ARMC7
Tdark
Novelty: 0.6
Score: 0.565
Data Source: STRINGDB
KIN
Tbio
Novelty: 0.00411331
Score: 0.516
Data Source: STRINGDB
GANC
Tchem
Family: Enzyme
Novelty: 0.02762131
Score: 0.514
Data Source: STRINGDB
INTS2
Tdark
Novelty: 0.76923077
Score: 0.509
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.81

PubMed score by year
PubTator Score  39.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer