Tbio AFG1L AFG1-like ATPase

Protein Summary

Description

Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain (PubMed:26759378, PubMed:27323408). Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress (PubMed:27323408). This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q8WV93
• Q8N6A3

Gene Name

• AFG1L

Ensembl ID

• ENST00000368977
• ENSP00000357973
• ENSG00000135537

Symbol

• AFG1
• LACE1
• AFG1
• LACE1
• c222389

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.03   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.03   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (8)

Functions (2)

Components (3)

Processes (3)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ATPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (24)

Explore Interacting Targets

1 – 10 of 24

• See Interactions on String-DB

SPATA5

Tbio

Family: Enzyme

Novelty: 0.00598222

Score: 0.967

Data Source: STRINGDB

ZAN

Tbio

Novelty: 0.01148836

Score: 0.71

Data Source: STRINGDB

CMTR2

Tbio

Family: Enzyme

Novelty: 0.00154741

Score: 0.702

Data Source: STRINGDB

TARBP2

Tbio

Novelty: 0.01962451

Score: 0.642

Data Source: STRINGDB

FAM169A

Tdark

Novelty: 1.40625

Score: 0.604

Data Source: STRINGDB

C6orf203

Tdark

Novelty: 0.625

Score: 0.563

Data Source: STRINGDB

TP53RK

Tbio

Family: Kinase

Novelty: 0.06549878

Score: 0.524

Data Source: STRINGDB

NKIRAS2

Tdark

Family: Enzyme

Novelty: 0.20963219

Score: 0.521

Data Source: STRINGDB

PLPP7

Tdark

Family: Enzyme

Novelty: 0.68965517

Score: 0.506

Data Source: STRINGDB

SDHB

Tbio

Family: Enzyme

Novelty: 0.0020679

Score: 0.493

Data Source: STRINGDB

Publication Statistics

PubMed Score  123.03

PubMed score by year

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PubTator Score  70.92

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MAASWSLLVTLRPLAQSPLRGRCVGCGAWAAALAPLATAPGKPFWKAYTVQTSESMTPTATSETYLKALA

1-70

VCHGPLDHYDFLIKAHELKDDEHQRRVIQCLQKLHEDLKGYNIEAEGLFSKLFSRSKPPRGLYVYGDVGT

70-140

GKTMVMDMFYAYVEMKRKKRVHFHGFMLDVHKRIHRLKQSLPKRKPGFMAKSYDPIAPIAEEISEEACLL

140-210

CFDEFQVTDIADAMILKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSG

210-280

IDYRKRELPAAGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTVADCTFEE

280-350

LCERPLGASDYLELSKNFDTIFLRNIPQFTLANRTQGRRFITLIDNFYDLKVRIICSASTPISSLFLHQH

350-420

HDSELEQSRILMDDLGLSQDSAEGLSMFTGEEEIFAFQRTISRLTEMQTEQYWNEGDRTKK

420-481

MAASWSLLVTLRPLAQSPLRGRCVGCGAWAAALAPLATAPGKPFWKAYTVQTSESMTPTATSETYLKALAVCHGPLDHYDFLIKAHELKDDEHQRRVIQCLQKLHEDLKGYNIEAEGLFSKLFSRSKPPRGLYVYGDVGTGKTMVMDMFYAYVEMKRKKRVHFHGFMLDVHKRIHRLKQSLPKRKPGFMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSGIDYRKRELPAAGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTVADCTFEELCERPLGASDYLELSKNFDTIFLRNIPQFTLANRTQGRRFITLIDNFYDLKVRIICSASTPISSLFLHQHHDSELEQSRILMDDLGLSQDSAEGLSMFTGEEEIFAFQRTISRLTEMQTEQYWNEGDRTKK

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Uniprot Keyword

ATP-binding
Complete proteome
Hydrolase
Membrane
Mitochondrion
Nucleotide-binding
Reference proteome