Tbio TRIM41 E3 ubiquitin-protein ligase TRIM41

Protein Summary

Description

Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q8WV44
• B3KNJ6
• D3DWR9
• Q5BKT0
• Q7L484
• Q96Q10
• Q9BSL8

Gene Name

• TRIM41

Ensembl ID

• ENST00000315073
• ENSP00000320869
• ENSG00000146063
• ENST00000351937
• ENSP00000336749

Symbol

• RINCK
• RINCK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.98
disease perturbation	0.9
transcription factor binding site profile	0.85
transcription factor	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.35   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.35   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0