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Tbio
TRIM41
E3 ubiquitin-protein ligase TRIM41

Protein Summary
Description
Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C. This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315073
  • ENSP00000320869
  • ENSG00000146063
  • ENST00000351937
  • ENSP00000336749

Symbol
  • RINCK
  • RINCK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.98
disease perturbation
0.9
transcription factor binding site profile
0.85
transcription factor
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.3   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.3   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2384814
211007
Rat
RGD:1308885
303088
Dog
tripartite motif containing 41
VGNC:47821
491669
Horse
tripartite motif containing 41
VGNC:24510
100057719
Cow
tripartite motif containing 41
VGNC:36334
540265
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tripartite motif containing 41
Horse
tripartite motif containing 41
Cow
tripartite motif containing 41
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WV44-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (313)
1 – 10 of 313
GLCCI1
Tbio
Novelty: 0.03220482
p_int: 0.999974352
p_ni: 0.000025615
p_wrong: 3.3e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
FARP2
Tbio
Novelty: 0.09590913
p_int: 0.999957048
p_ni: 0.000042952
Data Source: BioPlex
ZNF574
Tdark
Family: TF
Novelty: 2.72596185
p_int: 0.99994752
p_ni: 0.00005248
Score: 0.158
Data Source: BioPlex,STRINGDB
ZNF263
Tbio
Family: TF
Novelty: 0.098799
p_int: 0.999867455
p_ni: 0.0001325
p_wrong: 4.5e-8
Score: 0.168
Data Source: BioPlex,STRINGDB
ZNF669
Tdark
Family: TF
Novelty: 2.09725685
p_int: 0.99984018
p_ni: 0.000159786
p_wrong: 3.4e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999780778
p_ni: 0.000219217
p_wrong: 5e-9
Score: 0.25
Data Source: BioPlex,STRINGDB
APBA2
Tbio
Novelty: 0.01654185
p_int: 0.999699778
p_ni: 0.000299164
p_wrong: 0.000001059
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.9996721
p_ni: 0.0003279
Score: 0.152
Data Source: BioPlex,STRINGDB
PIP5K1A
Tbio
Family: Kinase
Novelty: 0.05039085
p_int: 0.999648754
p_ni: 0.000351245
p_wrong: 1e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
PRKCZ
Tchem
Family: Kinase
Novelty: 0.00201366
p_int: 0.999245634
p_ni: 0.000754365
p_wrong: 1e-9
Score: 0.329
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.30

PubMed score by year
PubTator Score  11.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer