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Tbio
BLNK
B-cell linker protein

Protein Classes
Protein Summary
Description
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224337
  • ENSP00000224337
  • ENSG00000095585
  • ENST00000371176
  • ENSP00000360218
  • ENST00000413476
  • ENSP00000397487

Symbol
  • BASH
  • SLP65
  • bca
  • AGM4
  • BASH
  • LY57
  • SLP65
  • BLNK-S
  • SLP-65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
gene perturbation
0.85
disease perturbation
0.83
hub protein
0.75
protein complex
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.38   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 663   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.38   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 663   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
56.6
mean corpuscular volume
1
1
1
46.1
sex hormone-binding globulin measurement
4
1
4
29.9
aging
1
1
1
24.5
smoking status measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
56.6
mean corpuscular volume
1
46.1
sex hormone-binding globulin measurement
4
29.9
aging
1
24.5
smoking status measurement
1
21.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
B cell linker
VGNC:3815
450641
Macaque
B-cell linker
704363
Mouse
MGI:96878
17060
Rat
RGD:1561933
499356
Dog
B cell linker
VGNC:38466
486814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
B cell linker
Macaque
B-cell linker
Mouse
Rat
Dog
B cell linker
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WV28-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Cytokine Signaling in Immune system
Immune System
Interleukin-3, Interleukin-5 and GM-CSF signaling
Protein-Protein Interactions (121)
1 – 10 of 121
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.997
Data Source:  Reactome,STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
Score:  0.992
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.988
Data Source:  Reactome,STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.982
Data Source:  STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.98
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.975
Data Source:  STRINGDB
NCK1
Tbio
Novelty:  0.00352084
Score:  0.97
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.968
Data Source:  Reactome,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.968
Data Source:  Reactome,STRINGDB
CD72
Tbio
Novelty:  0.00787437
Score:  0.968
Data Source:  STRINGDB
Publication Statistics
PubMed Score  288.38

PubMed score by year
PubTator Score  245.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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