Tbio DCAF4 DDB1- and CUL4-associated factor 4

Protein Summary

Description

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• Q8WV16
• B4DUT6
• G3V522
• Q86U31
• Q8IV10
• Q96K22
• Q9Y4P5

Gene Name

• DCAF4

Ensembl ID

• ENST00000358377
• ENSP00000351147
• ENSG00000119599
• ENST00000394234
• ENSP00000377781
• ENST00000509153
• ENSP00000426178
• ENST00000555042
• ENSP00000452131

Symbol

• WDR21
• WDR21A
• WDR21
• WDR21A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.85
histone modification site profile	0.84
transcription factor perturbation	0.74
disease	0.63
transcription factor	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.53   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.53   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0