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Tbio
CHMP7
Charged multivesicular body protein 7

Protein Summary
Description
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313219
  • ENSP00000324491
  • ENSG00000147457
  • ENST00000397677
  • ENSP00000380794
  • ENST00000519503
  • ENSP00000427948
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.96
virus perturbation
0.72
cell type or tissue
0.68
tissue
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
CHMP4A
Tbio
Novelty:  0.01163844
Score:  0.995
Data Source:  STRINGDB
CHMP5
Tbio
Novelty:  0.03378716
Score:  0.988
Data Source:  STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
Score:  0.986
Data Source:  STRINGDB
CHMP3
Tbio
Novelty:  0.01958573
Score:  0.983
Data Source:  STRINGDB
CHMP1B
Tbio
Novelty:  0.06982523
Score:  0.979
Data Source:  STRINGDB
VPS25
Tbio
Novelty:  0.03002488
Score:  0.974
Data Source:  STRINGDB
VPS4A
Tbio
Novelty:  0.01508121
Score:  0.962
Data Source:  STRINGDB
VTA1
Tbio
Novelty:  0.01697854
Score:  0.961
Data Source:  STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
Score:  0.959
Data Source:  STRINGDB
CHMP4B
Tbio
Novelty:  0.01391352
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Cellular responses to external stimuli
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Autophagy
Budding and maturation of HIV virion
Cellular responses to external stimuli
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
76.5
4
2
0
1.1
68.5
appendicular lean mass
2
1
2
67.1
TNF-related activation-induced cytokine measurement
1
1
1
39.6
serum non-albumin protein measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
76.5
0
1.1
68.5
appendicular lean mass
2
67.1
TNF-related activation-induced cytokine measurement
1
39.6
serum non-albumin protein measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 7
VGNC:907
743221
Macaque
charged multivesicular body protein 7
710050
Mouse
MGI:1913922
105513
Rat
RGD:1308779
364419
Dog
charged multivesicular body protein 7
608924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 7
Macaque
charged multivesicular body protein 7
Mouse
Rat
Dog
charged multivesicular body protein 7
Publication Statistics
PubMed Score 10.88
PubMed score by year
PubTator Score 3.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title