CHMP7
Charged multivesicular body protein 7
Protein Summary
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).
- ENST00000313219
- ENSP00000324491
- ENSG00000147457
- ENST00000397677
- ENSP00000380794
- ENST00000519503
- ENSP00000427948
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
kinase perturbation | 0.96 | ||
virus perturbation | 0.72 | ||
cell type or tissue | 0.68 | ||
tissue | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.88 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 58 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.88 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 58 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (61)
Nearest Tclin Targets
Pathways (15)
Reactome (13)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Budding and maturation of HIV virion | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Disease | ||||
Reactome | Endosomal Sorting Complex Required For Transport (ESCRT) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autophagy | ||||
Budding and maturation of HIV virion | ||||
Cellular responses to external stimuli | ||||
Disease | ||||
Endosomal Sorting Complex Required For Transport (ESCRT) | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (1)
Components (4)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 76.5 | |||||
4 | 2 | 0 | 1.1 | 68.5 | |||||
appendicular lean mass | 2 | 1 | 2 | 67.1 | |||||
TNF-related activation-induced cytokine measurement | 1 | 1 | 1 | 39.6 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 76.5 | |||||
0 | 1.1 | 68.5 | |||||
appendicular lean mass | 2 | 67.1 | |||||
TNF-related activation-induced cytokine measurement | 1 | 39.6 | |||||
serum non-albumin protein measurement | 1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | charged multivesicular body protein 7 | VGNC:907 | 743221 | |||||
Macaque | charged multivesicular body protein 7 | 710050 | ||||||
Mouse | MGI:1913922 | 105513 | ||||||
Rat | RGD:1308779 | 364419 | ||||||
Dog | charged multivesicular body protein 7 | 608924 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | charged multivesicular body protein 7 | |||||
Macaque | charged multivesicular body protein 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | charged multivesicular body protein 7 | |||||
Publication Statistics
PubMed Score 10.88
PubMed score by year
PubTator Score 3.20
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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