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Tbio
SLC38A5
Sodium-coupled neutral amino acid transporter 5

Protein Summary
Description
Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium. The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000595796
  • ENSP00000471683
  • ENSG00000017483
  • ENST00000619100
  • ENSP00000478807
  • ENST00000620913
  • ENSP00000481291

Symbol
  • JM24
  • SN2
  • SNAT5
  • SN2
  • JM24
  • SNAT5
  • pp7194
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
PubMedID
0.64
disease perturbation
0.62
gene perturbation
0.6
tissue sample
0.59


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.7   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.7   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 38 member 5
710156
Mouse
MGI:2148066
209837
Rat
RGD:620702
192208
Dog
solute carrier family 38 member 5
VGNC:54601
612527
Horse
solute carrier family 38 member 5
VGNC:23194
100051531
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 38 member 5
Mouse
Rat
Dog
solute carrier family 38 member 5
Horse
solute carrier family 38 member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WUX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (45)
1 – 10 of 45
SLC38A3
Tbio
Family: Transporter
Novelty: 0.00086533
Score: 0.807
Data Source: STRINGDB
PCTP
Tbio
Novelty: 0.00801213
Score: 0.804
Data Source: STRINGDB
JMJD4
Tbio
Novelty: 0.09951585
Score: 0.745
Data Source: STRINGDB
SCN11A
Tclin
Family: IC
Novelty: 0.00145294
Score: 0.745
Data Source: STRINGDB
FTSJ1
Tbio
Family: Enzyme
Novelty: 0.01511808
Score: 0.723
Data Source: STRINGDB
ALKBH1
Tbio
Family: Enzyme
Novelty: 0.00504781
Score: 0.714
Data Source: STRINGDB
SLC1A5
Tchem
Family: Transporter
Novelty: 0.00201741
Score: 0.672
Data Source: STRINGDB
GCNT2
Tbio
Family: Enzyme
Novelty: 0.03945461
Score: 0.621
Data Source: STRINGDB
SLC1A7
Tchem
Family: Transporter
Novelty: 0.00067678
Score: 0.593
Data Source: STRINGDB
PAF1
Tbio
Family: Enzyme
Novelty: 0.00200047
Score: 0.59
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.70

PubMed score by year
PubTator Score  562.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer