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Tbio
BRK1
Protein BRICK1

Protein Summary
Description
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000530758
  • ENSP00000432472
  • ENSG00000254999

Symbol
  • C3orf10
  • MDS027
  • hHBrk1
  • C3orf10
  • HSPC300
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
virus perturbation
0.95
kinase perturbation
0.81
transcription factor binding site profile
0.78
small molecule perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.85   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.85   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (153)
NCKAP1L
Tbio
Novelty:  0.03392474
p_int:  0.999999995
p_ni:  5e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
WASF1
Tbio
Novelty:  0.00977488
p_int:  0.999999991
p_ni:  9e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ABI1
Tbio
Novelty:  0.00796638
p_int:  0.999999989
p_ni:  1.2e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
ULK1
Tchem
Family:  Kinase
Novelty:  0.00240301
p_int:  0.999999985
p_ni:  1.4e-8
p_wrong:  1e-9
Data Source:  BioPlex
HSBP1
Tbio
Novelty:  0.09422832
p_int:  0.999999975
p_ni:  2.5e-8
Score:  0.457
Data Source:  BioPlex,STRINGDB
NHSL1
Tdark
Novelty:  0.28557146
p_int:  0.999999933
p_ni:  3.9e-8
p_wrong:  2.9e-8
Score:  0.444
Data Source:  BioPlex,STRINGDB
RB1CC1
Tbio
Novelty:  0.00744817
p_int:  0.999999927
p_ni:  7.2e-8
Data Source:  BioPlex
ATG13
Tbio
Novelty:  0.00951471
p_int:  0.999999907
p_ni:  7.8e-8
p_wrong:  1.5e-8
Data Source:  BioPlex
CEP89
Tbio
Novelty:  0.17461805
p_int:  0.999999901
p_ni:  9.8e-8
p_wrong:  2e-9
Data Source:  BioPlex
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
p_int:  0.999999898
p_ni:  1.02e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
4
91.6
eosinophil percentage of leukocytes
2
3
3
83.3
BMI-adjusted hip circumference
2
2
3
59
eosinophil percentage of granulocytes
1
1
1
40.7
sum of eosinophil and basophil counts
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.6
eosinophil percentage of leukocytes
3
83.3
BMI-adjusted hip circumference
3
59
eosinophil percentage of granulocytes
1
40.7
sum of eosinophil and basophil counts
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BRICK1, SCAR/WAVE actin nucleating complex subunit
VGNC:9658
100608101
Mouse
MGI:1915406
101314
Rat
RGD:1598136
679934
Dog
BRICK1, SCAR/WAVE actin nucleating complex subunit
VGNC:54277
607701
Horse
BRICK1, SCAR/WAVE actin nucleating complex subunit [Source:HGNC Symbol;Acc:HGNC:23057]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BRICK1, SCAR/WAVE actin nucleating complex subunit
Mouse
Rat
Dog
BRICK1, SCAR/WAVE actin nucleating complex subunit
Horse
BRICK1, SCAR/WAVE actin nucleating complex subunit [Source:HGNC Symbol;Acc:HGNC:23057]
Publication Statistics
PubMed Score 44.85
PubMed score by year
PubTator Score 15.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title