Protein Summary
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
- ENST00000530758
- ENSP00000432472
- ENSG00000254999
- C3orf10
- MDS027
- hHBrk1
- C3orf10
- HSPC300
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.96 | ||
virus perturbation | 0.95 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.78 | ||
small molecule perturbation | 0.75 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.85 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 84 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.85 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 84 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (153)
1 – 10 of 153
NCKAP1L
Novelty: 0.03392474
p_int: 0.999999995
p_ni: 5e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
WASF1
Novelty: 0.00977488
p_int: 0.999999991
p_ni: 9e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI1
Novelty: 0.00796638
p_int: 0.999999989
p_ni: 1.2e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
ULK1
Family: Kinase
Novelty: 0.00240301
p_int: 0.999999985
p_ni: 1.4e-8
p_wrong: 1e-9
Data Source: BioPlex
HSBP1
Novelty: 0.09422832
p_int: 0.999999975
p_ni: 2.5e-8
Score: 0.457
Data Source: BioPlex,STRINGDB
NHSL1
Novelty: 0.28557146
p_int: 0.999999933
p_ni: 3.9e-8
p_wrong: 2.9e-8
Score: 0.444
Data Source: BioPlex,STRINGDB
RB1CC1
Novelty: 0.00744817
p_int: 0.999999927
p_ni: 7.2e-8
Data Source: BioPlex
ATG13
Novelty: 0.00951471
p_int: 0.999999907
p_ni: 7.8e-8
p_wrong: 1.5e-8
Data Source: BioPlex
CEP89
Novelty: 0.17461805
p_int: 0.999999901
p_ni: 9.8e-8
p_wrong: 2e-9
Data Source: BioPlex
SETDB1
Family: TF; Epigenetic
Novelty: 0.00609294
p_int: 0.999999898
p_ni: 1.02e-7
Data Source: BioPlex
Pathways (16)
Reactome (11)
KEGG (1)
PathwayCommons (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate WASPs and WAVEs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Immune System | ||||
Innate Immune System | ||||
RHO GTPase Effectors | ||||
RHO GTPases Activate WASPs and WAVEs | ||||
Gene Ontology Terms (17)
Functions (1)
Components (5)
Processes (11)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 3 | 4 | 91.6 | |||||
eosinophil percentage of leukocytes | 2 | 3 | 3 | 83.3 | |||||
BMI-adjusted hip circumference | 2 | 2 | 3 | 59 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 40.7 | |||||
sum of eosinophil and basophil counts | 1 | 1 | 1 | 28.1 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 4 | 91.6 | |||||
eosinophil percentage of leukocytes | 3 | 83.3 | |||||
BMI-adjusted hip circumference | 3 | 59 | |||||
eosinophil percentage of granulocytes | 1 | 40.7 | |||||
sum of eosinophil and basophil counts | 1 | 28.1 | |||||
Find similar targets by:
UniProt Keyword
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GWAS Trait
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MGI Phenotype
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Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | BRICK1, SCAR/WAVE actin nucleating complex subunit | VGNC:9658 | 100608101 | |||||
Mouse | MGI:1915406 | 101314 | ||||||
Rat | RGD:1598136 | 679934 | ||||||
Dog | BRICK1, SCAR/WAVE actin nucleating complex subunit | VGNC:54277 | 607701 | |||||
Horse | BRICK1, SCAR/WAVE actin nucleating complex subunit [Source:HGNC Symbol;Acc:HGNC:23057] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | BRICK1, SCAR/WAVE actin nucleating complex subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | BRICK1, SCAR/WAVE actin nucleating complex subunit | |||||
Horse | BRICK1, SCAR/WAVE actin nucleating complex subunit [Source:HGNC Symbol;Acc:HGNC:23057] | |||||
Publication Statistics
PubMed Score 44.85
PubMed score by year
PubTator Score 15.49
PubTator score by year