Protein Summary
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
- ENST00000530758
- ENSP00000432472
- ENSG00000254999
- C3orf10
- MDS027
- hHBrk1
- C3orf10
- HSPC300
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.96 | ||
virus perturbation | 0.95 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.78 | ||
small molecule perturbation | 0.75 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.87 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 84 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.87 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 84 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (11)
KEGG (1)
PathwayCommons (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate WASPs and WAVEs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Immune System | ||||
Innate Immune System | ||||
RHO GTPase Effectors | ||||
RHO GTPases Activate WASPs and WAVEs | ||||
Gene Ontology Terms (17)
Functions (1)
Components (5)
Processes (11)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (153)
1 – 10 of 153
NCKAP1L
Novelty: 0.03392474
p_int: 0.999999995
p_ni: 5e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
WASF1
Novelty: 0.00977488
p_int: 0.999999991
p_ni: 9e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI1
Novelty: 0.00796638
p_int: 0.999999989
p_ni: 1.2e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
ULK1
Family: Kinase
Novelty: 0.00240301
p_int: 0.999999985
p_ni: 1.4e-8
p_wrong: 1e-9
Data Source: BioPlex
HSBP1
Novelty: 0.09422832
p_int: 0.999999975
p_ni: 2.5e-8
Score: 0.457
Data Source: BioPlex,STRINGDB
NHSL1
Novelty: 0.28557146
p_int: 0.999999933
p_ni: 3.9e-8
p_wrong: 2.9e-8
Score: 0.444
Data Source: BioPlex,STRINGDB
RB1CC1
Novelty: 0.00744817
p_int: 0.999999927
p_ni: 7.2e-8
Data Source: BioPlex
ATG13
Novelty: 0.00951471
p_int: 0.999999907
p_ni: 7.8e-8
p_wrong: 1.5e-8
Data Source: BioPlex
CEP89
Novelty: 0.17461805
p_int: 0.999999901
p_ni: 9.8e-8
p_wrong: 2e-9
Data Source: BioPlex
SETDB1
Family: TF; Epigenetic
Novelty: 0.00609294
p_int: 0.999999898
p_ni: 1.02e-7
Data Source: BioPlex
Publication Statistics
PubMed Score 42.87
PubMed score by year
PubTator Score 15.49
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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