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Tbio
BRK1
Protein BRICK1

Protein Summary
Description
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000530758
  • ENSP00000432472
  • ENSG00000254999

Symbol
  • C3orf10
  • MDS027
  • hHBrk1
  • C3orf10
  • HSPC300
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
virus perturbation
0.95
kinase perturbation
0.81
transcription factor binding site profile
0.78
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.87   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.87   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (153)
1 – 10 of 153
NCKAP1L
Tbio
Novelty: 0.03392474
p_int: 0.999999995
p_ni: 5e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
WASF1
Tbio
Novelty: 0.00977488
p_int: 0.999999991
p_ni: 9e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI1
Tbio
Novelty: 0.00796638
p_int: 0.999999989
p_ni: 1.2e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
ULK1
Tchem
Family: Kinase
Novelty: 0.00240301
p_int: 0.999999985
p_ni: 1.4e-8
p_wrong: 1e-9
Data Source: BioPlex
HSBP1
Tbio
Novelty: 0.09422832
p_int: 0.999999975
p_ni: 2.5e-8
Score: 0.457
Data Source: BioPlex,STRINGDB
NHSL1
Tdark
Novelty: 0.28557146
p_int: 0.999999933
p_ni: 3.9e-8
p_wrong: 2.9e-8
Score: 0.444
Data Source: BioPlex,STRINGDB
RB1CC1
Tbio
Novelty: 0.00744817
p_int: 0.999999927
p_ni: 7.2e-8
Data Source: BioPlex
ATG13
Tbio
Novelty: 0.00951471
p_int: 0.999999907
p_ni: 7.8e-8
p_wrong: 1.5e-8
Data Source: BioPlex
CEP89
Tbio
Novelty: 0.17461805
p_int: 0.999999901
p_ni: 9.8e-8
p_wrong: 2e-9
Data Source: BioPlex
SETDB1
Tbio
Family: TF; Epigenetic
Novelty: 0.00609294
p_int: 0.999999898
p_ni: 1.02e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  42.87

PubMed score by year
PubTator Score  15.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer