Protein Summary
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.
- ENST00000221899
- ENSP00000221899
- ENSG00000105298
- ENST00000248420
- ENSP00000248420
- ENST00000429344
- ENSP00000415078
- ENST00000585942
- ENSP00000465751
- C19orf29
- fSAPc
- C19orf29
- NY-REN-24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.91 | ||
histone modification site profile | 0.8 | ||
drug perturbation | 0.71 | ||
transcription factor perturbation | 0.68 | ||
transcription factor | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.17 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 77 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33.17 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 77 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (47)
CXorf56
Novelty: 0.39137617
p_int: 0.999991936
p_ni: 0.000008062
p_wrong: 2e-9
Score: 0.712
Data Source: BioPlex,STRINGDB
DHX8
Family: Enzyme
Novelty: 0.01584745
p_int: 0.99998626
p_ni: 0.00001374
Score: 0.865
Data Source: BioPlex,STRINGDB
CSNK2B
Family: Kinase
Novelty: 0.00152367
p_int: 0.999976957
p_ni: 0.000023043
Data Source: BioPlex
JMJD6
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999927614
p_ni: 0.000072386
Score: 0.173
Data Source: BioPlex,STRINGDB
CHCHD2
Novelty: 0.01615338
p_int: 0.999903916
p_ni: 0.000096082
p_wrong: 2e-9
Data Source: BioPlex
RNASEH1
Family: Enzyme
Novelty: 0.01838314
p_int: 0.999798518
p_ni: 0.00020147
p_wrong: 1.2e-8
Data Source: BioPlex
CLEC3A
Novelty: 0.21498836
p_int: 0.99976196
p_ni: 0.000238036
p_wrong: 4e-9
Score: 0.15
Data Source: BioPlex,STRINGDB
LLGL2
Novelty: 0.07084531
p_int: 0.999732583
p_ni: 0.000266223
p_wrong: 0.000001193
Data Source: BioPlex
NKAPD1
Novelty: 1.56979675
p_int: 0.994963748
p_ni: 0.004568244
p_wrong: 0.000468008
Score: 0.193
Data Source: BioPlex,STRINGDB
CHCHD10
Novelty: 0.01659548
p_int: 0.992943528
p_ni: 0.004667404
p_wrong: 0.002389068
Score: 0.289
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (1)
Components (5)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 1 | 2 | 62.6 | |||||
1 | 1 | 0 | 1.5 | 39.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 2 | 62.6 | |||||
0 | 1.5 | 39.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cactin, spliceosome C complex subunit | VGNC:10940 | 735884 | |||||
Mouse | MGI:1917562 | 70312 | ||||||
Rat | RGD:1563634 | 500790 | ||||||
Dog | cactin, spliceosome C complex subunit | VGNC:38653 | 485055 | |||||
Cow | cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cactin, spliceosome C complex subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | cactin, spliceosome C complex subunit | |||||
Cow | cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938] | |||||
Publication Statistics
PubMed Score 33.17
PubMed score by year
PubTator Score 5.67
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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