Tbio CACTIN Cactin

Protein Summary

Description

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.

Uniprot Accession IDs

• Q8WUQ7
• A6NNA9
• A9UL12
• O75229
• Q7LE08
• Q9BTA6
• Q9Y5A4

Gene Name

• CACTIN

Ensembl ID

• ENST00000221899
• ENSP00000221899
• ENSG00000105298
• ENST00000248420
• ENSP00000248420
• ENST00000429344
• ENSP00000415078
• ENST00000585942
• ENSP00000465751

Symbol

• C19orf29
• fSAPc
• C19orf29
• NY-REN-24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.91
histone modification site profile	0.8
drug perturbation	0.71
transcription factor perturbation	0.68
transcription factor	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.7   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.7   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0