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Tbio
CACTIN
Cactin

Protein Summary
Description
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221899
  • ENSP00000221899
  • ENSG00000105298
  • ENST00000248420
  • ENSP00000248420
  • ENST00000429344
  • ENSP00000415078
  • ENST00000585942
  • ENSP00000465751

Symbol
  • C19orf29
  • fSAPc
  • C19orf29
  • NY-REN-24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
histone modification site profile
0.8
drug perturbation
0.71
transcription factor perturbation
0.68
transcription factor
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
CXorf56
Tdark
Novelty:  0.39137617
p_int:  0.999991936
p_ni:  0.000008062
p_wrong:  2e-9
Score:  0.712
Data Source:  BioPlex,STRINGDB
DHX8
Tbio
Family:  Enzyme
Novelty:  0.01584745
p_int:  0.99998626
p_ni:  0.00001374
Score:  0.865
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999976957
p_ni:  0.000023043
Data Source:  BioPlex
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999927614
p_ni:  0.000072386
Score:  0.173
Data Source:  BioPlex,STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999903916
p_ni:  0.000096082
p_wrong:  2e-9
Data Source:  BioPlex
RNASEH1
Tchem
Family:  Enzyme
Novelty:  0.01838314
p_int:  0.999798518
p_ni:  0.00020147
p_wrong:  1.2e-8
Data Source:  BioPlex
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.99976196
p_ni:  0.000238036
p_wrong:  4e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.999732583
p_ni:  0.000266223
p_wrong:  0.000001193
Data Source:  BioPlex
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.994963748
p_ni:  0.004568244
p_wrong:  0.000468008
Score:  0.193
Data Source:  BioPlex,STRINGDB
CHCHD10
Tbio
Novelty:  0.01659548
p_int:  0.992943528
p_ni:  0.004667404
p_wrong:  0.002389068
Score:  0.289
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
62.6
1
1
0
1.5
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
62.6
0
1.5
39.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cactin, spliceosome C complex subunit
VGNC:10940
735884
Mouse
MGI:1917562
70312
Rat
RGD:1563634
500790
Dog
cactin, spliceosome C complex subunit
VGNC:38653
485055
Cow
cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cactin, spliceosome C complex subunit
Mouse
Rat
Dog
cactin, spliceosome C complex subunit
Cow
cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938]
Publication Statistics
PubMed Score 33.17
PubMed score by year
PubTator Score 5.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title