Tbio CACTIN Cactin

Protein Summary

Description

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.

Uniprot Accession IDs

• Q8WUQ7
• A6NNA9
• A9UL12
• O75229
• Q7LE08
• Q9BTA6
• Q9Y5A4

Gene Name

• CACTIN

Ensembl ID

• ENST00000221899
• ENSP00000221899
• ENSG00000105298
• ENST00000248420
• ENSP00000248420
• ENST00000429344
• ENSP00000415078
• ENST00000585942
• ENSP00000465751

Symbol

• C19orf29
• fSAPc
• C19orf29
• NY-REN-24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.91
histone modification site profile	0.8
drug perturbation	0.71
transcription factor perturbation	0.68
transcription factor	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (47)

Explore Interacting Targets

1 – 10 of 47

• See Interactions on String-DB

CXorf56

Tdark

Novelty:  0.39137617

p_int:  0.999991936

p_ni:  0.000008062

p_wrong:  2e-9

Score:  0.712

Data Source:  BioPlex,STRINGDB

DHX8

Tbio

Family:  Enzyme

Novelty:  0.01584745

p_int:  0.99998626

p_ni:  0.00001374

Score:  0.865

Data Source:  BioPlex,STRINGDB

CSNK2B

Tbio

Family:  Kinase

Novelty:  0.00152367

p_int:  0.999976957

p_ni:  0.000023043

Data Source:  BioPlex

JMJD6

Tchem

Family:  Enzyme

Novelty:  0.00305479

p_int:  0.999927614

p_ni:  0.000072386

Score:  0.173

Data Source:  BioPlex,STRINGDB

CHCHD2

Tbio

Novelty:  0.01615338

p_int:  0.999903916

p_ni:  0.000096082

p_wrong:  2e-9

Data Source:  BioPlex

RNASEH1

Tchem

Family:  Enzyme

Novelty:  0.01838314

p_int:  0.999798518

p_ni:  0.00020147

p_wrong:  1.2e-8

Data Source:  BioPlex

CLEC3A

Tdark

Novelty:  0.21498836

p_int:  0.99976196

p_ni:  0.000238036

p_wrong:  4e-9

Score:  0.15

Data Source:  BioPlex,STRINGDB

LLGL2

Tbio

Novelty:  0.07084531

p_int:  0.999732583

p_ni:  0.000266223

p_wrong:  0.000001193

Data Source:  BioPlex

NKAPD1

Tdark

Novelty:  1.56979675

p_int:  0.994963748

p_ni:  0.004568244

p_wrong:  0.000468008

Score:  0.193

Data Source:  BioPlex,STRINGDB

CHCHD10

Tbio

Novelty:  0.01659548

p_int:  0.992943528

p_ni:  0.004667404

p_wrong:  0.002389068

Score:  0.289

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (20)

Functions (1)

Components (5)

Processes (14)

Find Similar Targets

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10

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GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2	1	2		62.6
cutaneous melanoma	EFO_0000389	1	1	0	1.5	39.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	2		62.6
cutaneous melanoma	EFO_0000389	0	1.5	39.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Developmental protein
Immunity
Innate immunity
Isopeptide bond
mRNA processing
mRNA splicing
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
cutaneous melanoma
red blood cell distribution width

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cactin, spliceosome C complex subunit	VGNC:10940	735884
Mouse	cactin, spliceosome C complex subunit	MGI:1917562	70312
Rat	cactin, spliceosome C complex subunit	RGD:1563634	500790
Dog	cactin, spliceosome C complex subunit	VGNC:38653	485055
Cow	cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cactin, spliceosome C complex subunit
Mouse	cactin, spliceosome C complex subunit
Rat	cactin, spliceosome C complex subunit
Dog	cactin, spliceosome C complex subunit
Cow	cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938]

Publication Statistics

PubMed Score 33.17

PubMed score by year

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PubTator Score 5.67

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title