Tbio FBLIM1 Filamin-binding LIM protein 1

Protein Summary

Description

Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WUP2
• B3KNY0
• Q5VVE0
• Q5VVE1
• Q8IX23
• Q96T00
• Q9UFD6
• FBLP-1

Gene Name

• FBLIM1

Ensembl ID

• ENST00000332305
• ENSP00000364920
• ENSG00000162458
• ENST00000375766
• ENSP00000364921
• ENST00000375771
• ENSP00000364926
• ENST00000441801
• ENSP00000416387

Symbol

• FBLP1
• CAL
• FBLP1
• FBLP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
transcription factor	0.71
PubMedID	0.65
cellular component	0.63
small molecule perturbation	0.63

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Filamin-binding Lim Protein 1

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Filamin-binding Lim Protein 1

Protein / Cell Junction Protein / Filamin-binding Lim Protein 1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Filamin-binding Lim Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.49   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.49   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0