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Tbio
PDCD6IP
Programmed cell death 6-interacting protein

Protein Summary
Description
Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes (PubMed:14739459). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:17853893, PubMed:17556548). Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis (PubMed:17853893, PubMed:17556548, PubMed:18641129). May play a role in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307296
  • ENSP00000307387
  • ENSG00000170248
  • ENST00000457054
  • ENSP00000411825

Symbol
  • AIP1
  • ALIX
  • KIAA1375
  • AIP1
  • ALIX
  • HP95
  • DRIP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.93
hub protein
0.92
transcription factor perturbation
0.91
transcription factor binding site profile
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.13   (req: < 5)
Gene RIFs: 96   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.13   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
62.5
waist-hip ratio
1
1
1
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
62.5
waist-hip ratio
1
57.1
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 6 interacting protein
VGNC:2503
470783
Macaque
programmed cell death 6 interacting protein
706636
Mouse
MGI:1333753
18571
Rat
RGD:68357
501083
Dog
programmed cell death 6 interacting protein
VGNC:44341
477015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 6 interacting protein
Macaque
programmed cell death 6 interacting protein
Mouse
Rat
Dog
programmed cell death 6 interacting protein
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WUM4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Budding and maturation of HIV virion (R-HSA-162588)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
HIV Infection
Reactome
HIV Life Cycle
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Budding and maturation of HIV virion
Disease
HIV Infection
HIV Life Cycle
Infectious disease
Protein-Protein Interactions (125)
1 – 10 of 125
CHMP4B
Tbio
Novelty: 0.01391352
Score: 0.995
Data Source: STRINGDB
CHMP4A
Tbio
Novelty: 0.01163844
Score: 0.992
Data Source: STRINGDB
TSG101
Tbio
Novelty: 0.00211746
Score: 0.992
Data Source: STRINGDB
CHMP4C
Tbio
Novelty: 0.07423155
Score: 0.99
Data Source: STRINGDB
VPS4B
Tbio
Novelty: 0.00788708
Score: 0.989
Data Source: STRINGDB
VPS4A
Tbio
Novelty: 0.01508121
Score: 0.979
Data Source: STRINGDB
VPS28
Tbio
Novelty: 0.02927315
Score: 0.979
Data Source: STRINGDB
CHMP6
Tbio
Novelty: 0.02931
Score: 0.978
Data Source: STRINGDB
CHMP2A
Tbio
Novelty: 0.00169253
Score: 0.967
Data Source: STRINGDB
CHMP5
Tbio
Novelty: 0.03378716
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.13

PubMed score by year
PubTator Score  162.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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