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Tbio
NUP133
Nuclear pore complex protein Nup133

Protein Summary
Description
Involved in poly(A)+ RNA transport. The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261396
  • ENSP00000261396
  • ENSG00000069248

Symbol
  • GAMOS8
  • NPHS18
  • hNUP133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
1
cellular component
0.92
histone modification site profile
0.92
transcription factor perturbation
0.8
hub protein
0.79


Related Tools
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GENEVA
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.83   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.83   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
39.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
39.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 133kDa
VGNC:1422
457804
Mouse
MGI:2442620
234865
Rat
RGD:1307827
292085
Dog
nucleoporin 133
VGNC:44045
479208
Horse
nucleoporin 133
VGNC:20960
100065427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 133kDa
Mouse
Rat
Dog
nucleoporin 133
Horse
nucleoporin 133
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WUM0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (86)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 81
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (296)
1 – 10 of 296
NUP98
Tbio
Family: Enzyme
Novelty: 0.00401452
p_int: 0.999953882
p_ni: 0.000046118
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP107
Tbio
Novelty: 0.01994155
p_int: 0.999915315
p_ni: 0.000084685
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP160
Tbio
Novelty: 0.03667026
p_int: 0.999650262
p_ni: 0.000349738
Score: 0.999
Data Source: BioPlex,STRINGDB
NUP85
Tbio
Novelty: 0.02350514
p_int: 0.998413864
p_ni: 0.001586136
Score: 0.999
Data Source: BioPlex,STRINGDB
PUS1
Tbio
Family: Enzyme
Novelty: 0.01923618
p_int: 0.995466887
p_ni: 0.004533113
Score: 0.157
Data Source: BioPlex,STRINGDB
NUP43
Tbio
Novelty: 0.11571309
p_int: 0.995424307
p_ni: 0.004575693
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SPAST
Tbio
Novelty: 0.00303236
p_int: 0.974678449
p_ni: 0.02532151
p_wrong: 4.1e-8
Score: 0.817
Data Source: BioPlex,STRINGDB
NUP37
Tbio
Novelty: 0.1270421
p_int: 0.969176224
p_ni: 0.030823776
Score: 0.998
Data Source: BioPlex,STRINGDB
SEC13
Tbio
Novelty: 0.00709413
p_int: 0.902902131
p_ni: 0.09709787
Score: 0.999
Data Source: BioPlex,STRINGDB
TPTE2
Tbio
Family: Enzyme
Novelty: 0.04710658
p_int: 0.864151859
p_ni: 0.135848138
p_wrong: 3e-9
Score: 0.219
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  50.83

PubMed score by year
PubTator Score  14.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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