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Tbio
PTPMT1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Protein Summary
Description
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326656
  • ENSP00000325882
  • ENSG00000110536
  • ENST00000326674
  • ENSP00000325958
  • ENST00000426530
  • ENSP00000410272
  • ENST00000643547
  • ENSP00000494387
  • ENSG00000285206
  • ENST00000646905
  • ENSP00000495288
  • ENST00000647378
  • ENSP00000496417

Symbol
  • MOSP
  • PLIP
  • MOSP
  • PLIP
  • DUSP23
  • PNAS-129
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor perturbation
0.8
protein domain
0.73
tissue sample
0.73
cellular component
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, mitochondrial 1
100610884
Rat
RGD:1589783
29390
Dog
protein tyrosine phosphatase, mitochondrial 1
VGNC:45166
483622
Horse
protein tyrosine phosphatase, mitochondrial 1
VGNC:22009
100058180
Cow
protein tyrosine phosphatase, mitochondrial 1
VGNC:33528
614890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, mitochondrial 1
Rat
Dog
protein tyrosine phosphatase, mitochondrial 1
Horse
protein tyrosine phosphatase, mitochondrial 1
Cow
protein tyrosine phosphatase, mitochondrial 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WUK0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PG
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PG
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (45)
1 – 10 of 45
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.994899225
p_ni: 0.005100775
Score: 0.156
Data Source: BioPlex,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.972777243
p_ni: 0.027222754
p_wrong: 3e-9
Data Source: BioPlex
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.962725575
p_ni: 0.037271567
p_wrong: 0.000002858
Data Source: BioPlex
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01135292
p_int: 0.938292305
p_ni: 0.061707695
Data Source: BioPlex
KLK1
Tchem
Family: Enzyme
Novelty: 0.00190157
p_int: 0.937104826
p_ni: 0.062894936
p_wrong: 2.38e-7
Data Source: BioPlex
CBWD1
Tbio
Novelty: 0.04321511
p_int: 0.895024572
p_ni: 0.104975428
Data Source: BioPlex
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.793602195
p_ni: 0.206397805
Data Source: BioPlex
SLC2A12
Tbio
Family: Transporter
Novelty: 0.01455533
p_int: 0.786041622
p_ni: 0.213814071
p_wrong: 0.000144307
Data Source: BioPlex
CD79A
Tbio
Novelty: 0.00118942
p_int: 0.783024768
p_ni: 0.216975185
p_wrong: 4.7e-8
Data Source: BioPlex
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
p_int: 0.772287138
p_ni: 0.227712862
Data Source: BioPlex
Publication Statistics
PubMed Score  25.07

PubMed score by year
PubTator Score  19.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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