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Tbio
STYX
Serine/threonine/tyrosine-interacting protein

Protein Summary
Description
Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity). The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354586
  • ENSP00000346599
  • ENSG00000198252
  • ENST00000442123
  • ENSP00000403214
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
virus perturbation
0.76
histone modification site profile
0.73
protein domain
0.73
microRNA
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.69   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.69   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999637306
p_ni:  0.000362099
p_wrong:  5.95e-7
Data Source:  BioPlex
ELP2
Tbio
Novelty:  0.03034629
p_int:  0.816011635
p_ni:  0.183988365
Data Source:  BioPlex
LEFTY1
Tbio
Novelty:  0.01608284
Score:  0.76
Data Source:  STRINGDB
GPR137C
Tdark
Novelty:  3.30248948
Score:  0.7
Data Source:  STRINGDB
CSDC2
Tbio
Family:  TF
Novelty:  0.08857607
Score:  0.695
Data Source:  STRINGDB
TXNDC16
Tdark
Novelty:  0.25365147
Score:  0.693
Data Source:  STRINGDB
PTPRN
Tbio
Family:  Enzyme
Novelty:  0.00076479
Score:  0.693
Data Source:  STRINGDB
CARHSP1
Tbio
Family:  TF
Novelty:  0.20939001
Score:  0.611
Data Source:  STRINGDB
PTPN23
Tbio
Family:  Enzyme
Novelty:  0.03578001
Score:  0.542
Data Source:  STRINGDB
NID2
Tbio
Novelty:  0.01638372
Score:  0.525
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
1
1
80.1
heel bone mineral density
2
3
3
69.9
1
1
0
1.1
19
blood protein measurement
1
1
1
10.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
80.1
heel bone mineral density
3
69.9
0
1.1
19
blood protein measurement
1
10.8
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine/tyrosine interacting protein
VGNC:12491
743004
Mouse
MGI:1891150
56291
Rat
RGD:1594806
100912536
Cow
serine/threonine/tyrosine interacting protein
VGNC:35452
616825
Pig
serine/threonine/tyrosine interacting protein
100517509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine/tyrosine interacting protein
Mouse
Rat
Cow
serine/threonine/tyrosine interacting protein
Pig
serine/threonine/tyrosine interacting protein
Publication Statistics
PubMed Score 20.69
PubMed score by year
PubTator Score 29.42
PubTator score by year
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Related Publications
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PMID
Year
Title