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Tbio
TGFBRAP1
Transforming growth factor-beta receptor-associated protein 1

Protein Summary
Description
Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but no ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258449
  • ENSP00000258449
  • ENSG00000135966
  • ENST00000393359
  • ENSP00000377027
  • ENST00000595531
  • ENSP00000471434

Symbol
  • VPS3
  • TRAP1
  • TRAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.73
disease perturbation
0.68
tissue sample
0.68
kinase perturbation
0.66
cell type or tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.65   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.65   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (118)
1 – 10 of 118
VPS11
Tbio
Novelty:  0.00496411
p_int:  0.999999933
p_ni:  6.4e-8
p_wrong:  3e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
VPS41
Tbio
Novelty:  0.08480171
p_int:  0.999999056
p_ni:  9.44e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
THRSP
Tbio
Novelty:  0.00938864
p_int:  0.999186623
p_ni:  0.000813377
p_wrong:  1e-9
Data Source:  BioPlex
ISOC2
Tbio
Family:  Enzyme
Novelty:  0.33841868
p_int:  0.99793729
p_ni:  0.002062696
p_wrong:  1.4e-8
Score:  0.535
Data Source:  BioPlex,STRINGDB
TMEM266
Tdark
Novelty:  0.26313861
p_int:  0.997269745
p_ni:  0.002730214
p_wrong:  4.1e-8
Score:  0.802
Data Source:  BioPlex,STRINGDB
LRRC61
Tdark
Novelty:  1.45343096
p_int:  0.996770564
p_ni:  0.003229435
p_wrong:  1e-9
Data Source:  BioPlex
CSTA
Tbio
Novelty:  0.00453121
p_int:  0.996238142
p_ni:  0.003761833
p_wrong:  2.5e-8
Data Source:  BioPlex
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.99243763
p_ni:  0.007562337
p_wrong:  3.3e-8
Data Source:  BioPlex
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.988704624
p_ni:  0.011293395
p_wrong:  0.000001981
Data Source:  BioPlex
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.986916377
p_ni:  0.013083621
p_wrong:  2e-9
Data Source:  BioPlex
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
PathwayCommons: pid
TGF-beta receptor signaling
Name
Explore in Pharos
Explore in Source
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
TGF-beta receptor signaling
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
1
2
59.6
age at menarche
2
2
2
57.7
diastolic blood pressure
1
1
1
48.5
body mass index
1
1
1
40.7
gait measurement
1
2
2
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
59.6
age at menarche
2
57.7
diastolic blood pressure
1
48.5
body mass index
1
40.7
gait measurement
2
36.5
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta receptor associated protein 1
VGNC:2921
470463
Macaque
transforming growth factor beta receptor associated protein 1
713102
Mouse
MGI:2447427
73122
Rat
RGD:1310772
301373
Dog
transforming growth factor beta receptor associated protein 1
VGNC:47313
481320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta receptor associated protein 1
Macaque
transforming growth factor beta receptor associated protein 1
Mouse
Rat
Dog
transforming growth factor beta receptor associated protein 1
Publication Statistics
PubMed Score 16.65
PubMed score by year
PubTator Score 7.22
PubTator score by year