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Tbio
CHURC1
Protein Churchill

Protein Summary
Description
Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000548752
  • ENSP00000450165
  • ENSG00000258289
  • ENST00000549115
  • ENSP00000448050
  • ENST00000607599
  • ENSP00000475473

Symbol
  • C14orf52
  • CHCH
  • chch
  • My015
  • C14orf52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
histone modification site profile
0.73
microRNA
0.66
tissue sample
0.63
small molecule perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
14.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (55)
1 – 10 of 55
NMT2
Tchem
Family: Enzyme
Novelty: 0.04826835
p_int: 0.999998282
p_ni: 0.000001718
Data Source: BioPlex
NMT1
Tchem
Family: Enzyme
Novelty: 0.00343834
p_int: 0.999420116
p_ni: 0.000579884
Data Source: BioPlex
ACTR3B
Tbio
Novelty: 0.06033214
p_int: 0.998993393
p_ni: 6.3e-8
p_wrong: 0.001006544
Score: 0.286
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.997574715
p_ni: 0.002424848
p_wrong: 4.37e-7
Data Source: BioPlex
MTMR14
Tbio
Family: Enzyme
Novelty: 0.07074944
p_int: 0.996234934
p_ni: 0.003765064
p_wrong: 1e-9
Data Source: BioPlex
ACTR2
Tbio
Novelty: 0.00731489
p_int: 0.975948134
p_ni: 0.024051866
Data Source: BioPlex
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
p_int: 0.765868302
p_ni: 0.233687647
p_wrong: 0.000444051
Data Source: BioPlex
GLRX
Tbio
Novelty: 0.00111903
p_int: 0.757488791
p_ni: 0.008064526
p_wrong: 0.234446684
Data Source: BioPlex
PLAG1
Tbio
Family: TF
Novelty: 0.00665136
Score: 0.8
Data Source: STRINGDB
PPIL6
Tdark
Family: Enzyme
Novelty: 1.46776073
Score: 0.721
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.25

PubMed score by year
PubTator Score  102.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer