SLC22A17
Solute carrier family 22 member 17
Protein Summary
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
- ENST00000397267
- ENSP00000380437
- ENSG00000092096
- ENST00000637426
- ENSP00000489868
- BOCT
- BOIT
- BOCT
- BOIT
- 24p3R
- NGALR
- hBOIT
- NGALR2
- NGALR3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.71 | ||
gene perturbation | 0.59 | ||
tissue | 0.56 | ||
tissue sample | 0.55 | ||
cell line | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.55 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.55 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0