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Tbio
SLC22A17
Solute carrier family 22 member 17

Protein Summary
Description
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397267
  • ENSP00000380437
  • ENSG00000092096
  • ENST00000637426
  • ENSP00000489868

Symbol
  • BOCT
  • BOIT
  • BOCT
  • BOIT
  • 24p3R
  • NGALR
  • hBOIT
  • NGALR2
  • NGALR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.71
gene perturbation
0.59
tissue
0.56
tissue sample
0.55
cell line
0.53


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.25   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.25   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 22 member 17
713765
Mouse
MGI:1926225
59049
Rat
RGD:631405
305886
Dog
solute carrier family 22 member 17
VGNC:51686
608168
Horse
solute carrier family 22 member 17
VGNC:51410
100146262
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 22 member 17
Mouse
Rat
Dog
solute carrier family 22 member 17
Horse
solute carrier family 22 member 17
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WUG5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Iron uptake and transport (R-HSA-917937)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Iron uptake and transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Iron uptake and transport
Transport of small molecules
Protein-Protein Interactions (34)
1 – 10 of 34
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.840698874
p_ni: 0.159301126
Data Source: BioPlex
LCN2
Tbio
Family: Enzyme
Novelty: 0.00034678
Score: 0.982
Data Source: Reactome,STRINGDB
STXBP6
Tbio
Novelty: 0.13195671
Score: 0.829
Data Source: STRINGDB
COCH
Tbio
Novelty: 0.00819355
Score: 0.8
Data Source: STRINGDB
LRP2
Tbio
Novelty: 0.00143258
Score: 0.702
Data Source: STRINGDB
CACNG7
Tdark
Family: IC
Novelty: 0.32460059
Score: 0.684
Data Source: STRINGDB
L3MBTL2
Tbio
Family: Epigenetic
Novelty: 0.11193867
Score: 0.668
Data Source: STRINGDB
PTMA
Tbio
Novelty: 0.00332415
Score: 0.623
Data Source: STRINGDB
NRXN2
Tbio
Novelty: 0.01252742
Score: 0.567
Data Source: STRINGDB
NRXN2
Tbio
Novelty: 0.01252742
Score: 0.567
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.25

PubMed score by year
PubTator Score  12.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer