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Tbio
FAM172A
Cotranscriptional regulator FAM172A

Protein Summary
Description
Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395965
  • ENSP00000379294
  • ENSG00000113391
  • ENST00000505869
  • ENSP00000426284
  • ENST00000509163
  • ENSP00000423841

Symbol
  • C5orf21
  • Toupee
  • C5orf21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
histone modification site profile
0.89
transcription factor binding site profile
0.65
cell type or tissue
0.62
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.8   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.8   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999765
p_ni:  2.3e-7
p_wrong:  5e-9
Data Source:  BioPlex
ZNF331
Tbio
Family:  TF
Novelty:  0.05976217
p_int:  0.999998113
p_ni:  0.000001887
Data Source:  BioPlex
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999997543
p_ni:  0.000002456
Score:  0.187
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.999995912
p_ni:  0.000004088
Data Source:  BioPlex
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.999789094
p_ni:  0.000210858
p_wrong:  4.9e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
KIR3DL2
Tbio
Novelty:  0.00321353
p_int:  0.999751924
p_ni:  0.000247994
p_wrong:  8.2e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
p_int:  0.998340371
p_ni:  0.001627757
p_wrong:  0.000031872
Score:  0.209
Data Source:  BioPlex,STRINGDB
PLAC8L1
Tdark
Novelty:  2.10744169
Score:  0.769
Data Source:  STRINGDB
GRIK3
Tclin
Family:  IC
Novelty:  0.01816701
Score:  0.653
Data Source:  STRINGDB
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
Score:  0.628
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
7
8
94.3
2
2
0
1
86.2
self reported educational attainment
1
3
3
84.6
cortical surface area measurement
1
3
0
31.7
77
diet measurement
3
3
3
60.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
8
94.3
0
1
86.2
self reported educational attainment
3
84.6
cortical surface area measurement
0
31.7
77
diet measurement
3
60.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 172 member A
VGNC:3990
737106
Macaque
family with sequence similarity 172 member A
697127
Mouse
MGI:1915925
68675
Rat
RGD:1305526
294606
Dog
family with sequence similarity 172 member A
VGNC:40625
102157038
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 172 member A
Macaque
family with sequence similarity 172 member A
Mouse
Rat
Dog
family with sequence similarity 172 member A
Publication Statistics
PubMed Score 14.80
PubMed score by year
PubTator Score 8.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title