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Tbio
PPP1R13L
RelA-associated inhibitor

Protein Summary
Description
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360957
  • ENSP00000354218
  • ENSG00000104881
  • ENST00000418234
  • ENSP00000403902

Symbol
  • IASPP
  • NKIP1
  • PPP1R13BL
  • RAI
  • RAI
  • RAI4
  • IASPP
  • NKIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
biological process
0.74
transcription factor
0.74
histone modification site profile
0.73
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.27   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.27   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Association with Co-factors
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Association with Co-factors
Protein-Protein Interactions (41)
1 – 10 of 41
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00685545
p_int: 0.999999992
p_ni: 1e-9
p_wrong: 7e-9
Score: 0.327
Data Source: BioPlex,STRINGDB
MAGEA4
Tbio
Novelty: 0.00987373
p_int: 0.999999726
p_ni: 2.74e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01762102
p_int: 0.999999462
p_ni: 5.38e-7
Data Source: BioPlex
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00538884
p_int: 0.999996407
p_ni: 0.000003593
Score: 0.35
Data Source: BioPlex,STRINGDB
WDR83
Tbio
Novelty: 0.06422509
p_int: 0.999984544
p_ni: 0.000015451
p_wrong: 5e-9
Data Source: BioPlex
MAPRE1
Tbio
Novelty: 0.01431078
p_int: 0.999965789
p_ni: 0.000034211
Score: 0.232
Data Source: BioPlex,STRINGDB
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.06135268
p_int: 0.995445381
p_ni: 0.004554618
Data Source: BioPlex
FAM19A3
Tdark
Novelty: 0.43478261
p_int: 0.993868015
p_ni: 0.002383311
p_wrong: 0.003748675
Data Source: BioPlex
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.987
Data Source: Reactome,STRINGDB
TP73
Tbio
Family: TF
Novelty: 0.00899658
Score: 0.962
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  80.27

PubMed score by year
PubTator Score  66.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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