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Tbio
CHPT1
Cholinephosphotransferase 1

Protein Classes
Protein Summary
Description
Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
metabolite
0.97
kinase perturbation
0.91
disease perturbation
0.9
PubMedID
0.86


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.84   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.84   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
choline phosphotransferase 1
VGNC:5339
467109
Macaque
choline phosphotransferase 1
696056
Mouse
MGI:2384841
212862
Rat
RGD:1359283
362866
Dog
choline phosphotransferase 1
VGNC:54196
610214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
choline phosphotransferase 1
Macaque
choline phosphotransferase 1
Mouse
Rat
Dog
choline phosphotransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WUD6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (131)
1 – 10 of 131
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
p_int: 0.978665897
p_ni: 0.021267949
p_wrong: 0.000066154
Data Source: BioPlex
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02212992
p_int: 0.976386491
p_ni: 0.023595017
p_wrong: 0.000018492
Data Source: BioPlex
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.975336816
p_ni: 0.023935787
p_wrong: 0.000727397
Data Source: BioPlex
CD70
Tbio
Novelty: 0.00420393
p_int: 0.968539968
p_ni: 0.031380073
p_wrong: 0.000079959
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.967486134
p_ni: 0.014361862
p_wrong: 0.018152004
Data Source: BioPlex
OPRM1
Tclin
Family: GPCR
Novelty: 0.0003701
p_int: 0.946127302
p_ni: 0.053357773
p_wrong: 0.000514925
Data Source: BioPlex
TMEM171
Tdark
Novelty: 2.00247773
p_int: 0.941837365
p_ni: 0.029749548
p_wrong: 0.028413087
Data Source: BioPlex
ERGIC3
Tbio
Novelty: 0.11095443
p_int: 0.936643826
p_ni: 0.06329727
p_wrong: 0.000058904
Score: 0.161
Data Source: BioPlex,STRINGDB
SLC22A6
Tclin
Family: Transporter
Novelty: 0.00389149
p_int: 0.901052592
p_ni: 0.098112417
p_wrong: 0.000834991
Data Source: BioPlex
LRRC8B
Tbio
Novelty: 0.16457267
p_int: 0.88835382
p_ni: 0.110210367
p_wrong: 0.001435813
Data Source: BioPlex
Publication Statistics
PubMed Score  31.84

PubMed score by year
PubTator Score  138.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer