You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RAB2B
Ras-related protein Rab-2B

Protein Summary
Description
Required for protein transport from the endoplasmic reticulum to the Golgi complex. Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397762
  • ENSP00000380869
  • ENSG00000129472
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.91
kinase perturbation
0.91
molecular function
0.91
virus perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.42   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.42   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (120)
1 – 10 of 120
FAM71F2
Tdark
Novelty:  0.56916996
p_int:  0.999999889
p_ni:  1.11e-7
Score:  0.903
Data Source:  BioPlex,STRINGDB
RAB2A
Tchem
Family:  Enzyme
Novelty:  0.00629151
p_int:  0.999999485
p_ni:  5.14e-7
p_wrong:  1e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.999998083
p_ni:  0.000001917
Score:  0.922
Data Source:  BioPlex,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999997451
p_ni:  0.000002549
Score:  0.927
Data Source:  BioPlex,STRINGDB
PGGT1B
Tchem
Family:  Enzyme
Novelty:  0.08041103
p_int:  0.9999958
p_ni:  0.000004197
p_wrong:  2e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999989479
p_ni:  0.000010521
Score:  0.827
Data Source:  BioPlex,STRINGDB
RAB5B
Tbio
Family:  Enzyme
Novelty:  0.02653775
p_int:  0.999938851
p_ni:  0.000060279
p_wrong:  8.71e-7
Score:  0.97
Data Source:  BioPlex,STRINGDB
RAB14
Tbio
Family:  Enzyme
Novelty:  0.01876172
p_int:  0.999626951
p_ni:  0.000373049
Score:  0.985
Data Source:  BioPlex,STRINGDB
BTAF1
Tbio
Novelty:  0.01586704
p_int:  0.999621468
p_ni:  0.000378532
Data Source:  BioPlex
PRUNE1
Tchem
Novelty:  0.02136836
p_int:  0.999535437
p_ni:  0.000464528
p_wrong:  3.5e-8
Score:  0.212
Data Source:  BioPlex,STRINGDB
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
77.9
diet measurement
1
1
1
71.2
self reported educational attainment
1
1
1
59
BMI-adjusted hip circumference
1
1
1
47.7
smoking status measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
77.9
diet measurement
1
71.2
self reported educational attainment
1
59
BMI-adjusted hip circumference
1
47.7
smoking status measurement
1
15.8
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB2B, member RAS oncogene family
452763
Macaque
RAB2B, member RAS oncogene family
708273
Mouse
MGI:1923588
76338
Rat
RGD:1309117
305853
Dog
RAB2B, member RAS oncogene family
VGNC:45272
475402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB2B, member RAS oncogene family
Macaque
RAB2B, member RAS oncogene family
Mouse
Rat
Dog
RAB2B, member RAS oncogene family
Publication Statistics
PubMed Score 5.42
PubMed score by year
PubTator Score 3.59
PubTator score by year