Tbio PHF10 PHD finger protein 10

Protein Summary

Description

Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WUB8
• Q2YDA3
• Q53HG8
• Q9BXD2
• Q9NV26

Gene Name

• PHF10

Ensembl ID

• ENST00000339209
• ENSP00000341805
• ENSG00000130024
• ENST00000366780
• ENSP00000355743
• ENST00000621772
• ENSP00000484117

Symbol

• BAF45A
• BAF45A
• XAP135

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
transcription factor perturbation	0.88
histone modification site profile	0.85
ligand (protein) perturbation	0.83
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Phd Finger Protein 10

Protein / Transcription Factor / Zinc Finger Transcription Factor / Phd Finger Protein 10

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Phd Finger Protein 10

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Phd Finger Protein 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.99   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.99   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

CHCHD2

Tbio

Novelty:  0.01615338

p_int:  0.999998387

p_ni:  0.000001613

Data Source:  BioPlex

CLEC3A

Tdark

Novelty:  0.21498836

p_int:  0.999993971

p_ni:  0.000006029

Data Source:  BioPlex

SMARCC2

Tbio

Family:  TF; Epigenetic

Novelty:  0.02625321

p_int:  0.999991171

p_ni:  0.000008829

Score:  0.983

Data Source:  BioPlex,STRINGDB

SMARCB1

Tbio

Novelty:  0.00116387

p_int:  0.999983278

p_ni:  0.000016722

Score:  0.979

Data Source:  BioPlex,STRINGDB

SMARCD1

Tbio

Novelty:  0.03176642

p_int:  0.99998318

p_ni:  0.00001682

Score:  0.991

Data Source:  BioPlex,STRINGDB

PRM2

Tbio

Novelty:  0.0050028

p_int:  0.999973537

p_ni:  0.000026463

Data Source:  BioPlex

BCL7C

Tdark

Novelty:  0.31203802

p_int:  0.999964481

p_ni:  0.000035519

Score:  0.749

Data Source:  BioPlex,STRINGDB

DDX50

Tbio

Family:  Enzyme

Novelty:  0.05314506

p_int:  0.999806242

p_ni:  0.000193757

p_wrong:  1e-9

Data Source:  BioPlex

NUP50

Tbio

Novelty:  0.03424725

p_int:  0.999745475

p_ni:  0.000254525

Score:  0.528

Data Source:  BioPlex,STRINGDB

ZNF385C

Tdark

Novelty:  2.23931637

p_int:  0.999737638

p_ni:  0.00026236

p_wrong:  2e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Hepatocellular carcinoma	168 targets	path:hsa05225

Name	Explore in Pharos	Explore in Source
Hepatocellular carcinoma	168 targets	path:hsa05225

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (3)

Components (4)

Processes (3)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
histone acetyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
histone binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1	1	1		44.2
neutrophil count	EFO_0004833	1	1	1		40.7
smoking status measurement	EFO_0006527	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1		44.2
neutrophil count	EFO_0004833	1		40.7
smoking status measurement	EFO_0006527	1		24.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Isopeptide bond
Metal-binding
Neurogenesis
Nucleus
Phosphoprotein
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
neutrophil count
self reported educational attainment
smoking status measurement

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	PHD finger protein 10	VGNC:3615	463140
Macaque	PHD finger protein 10		695325
Mouse	PHD finger protein 10	MGI:1919307	72057
Rat	PHD finger protein 10	RGD:1305266	292404
Dog	PHD finger protein 10	VGNC:44480	475037

Species	Name	OMA	EggNOG	Inparanoid
Chimp	PHD finger protein 10
Macaque	PHD finger protein 10
Mouse	PHD finger protein 10
Rat	PHD finger protein 10
Dog	PHD finger protein 10

Publication Statistics

PubMed Score 18.99

PubMed score by year

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PubTator Score 11.00

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (6)

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10

0 of 0

PMID	Year	Title