Tbio SMAP2 Stromal membrane-associated protein 2

Protein Summary

Description

GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).

Uniprot Accession IDs

• Q8WU79
• B2R7T1
• B7Z5B5
• B7Z8V2
• D3DPV2
• Q5QPL2
• Q96C93
• Q9NST2
• Q9UJL8

Gene Name

• SMAP2

Ensembl ID

• ENST00000372708
• ENSP00000361793
• ENSG00000084070
• ENST00000372718
• ENSP00000361803
• ENST00000539317
• ENSP00000442835

Symbol

• SMAP1L
• SMAP1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.86
virus perturbation	0.76
disease perturbation	0.68
interacting protein	0.65
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.32   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.32   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (40)

Explore Interacting Targets

1 – 10 of 40

• See Interactions on String-DB

MFSD4A

Tdark

Novelty:  0.62186415

p_int:  0.999944602

p_ni:  0.000055379

p_wrong:  1.9e-8

Score:  0.173

Data Source:  BioPlex,STRINGDB

SLC22A12

Tclin

Family:  Transporter

Novelty:  0.00318081

p_int:  0.999937991

p_ni:  0.000061654

p_wrong:  3.55e-7

Score:  0.309

Data Source:  BioPlex,STRINGDB

CLINT1

Tbio

Novelty:  0.00945381

p_int:  0.999929334

p_ni:  0.000070481

p_wrong:  1.85e-7

Score:  0.248

Data Source:  BioPlex,STRINGDB

CELF5

Tbio

Novelty:  0.04733002

p_int:  0.999781953

p_ni:  0.000218041

p_wrong:  6e-9

Score:  0.195

Data Source:  BioPlex,STRINGDB

SLC2A4

Tchem

Family:  Transporter

Novelty:  0.00033701

p_int:  0.99969888

p_ni:  0.000287792

p_wrong:  0.000013328

Score:  0.455

Data Source:  BioPlex,STRINGDB

SLC25A11

Tbio

Family:  Transporter

Novelty:  0.06125899

p_int:  0.999523181

p_ni:  0.000476818

Score:  0.225

Data Source:  BioPlex,STRINGDB

STAMBPL1

Tbio

Family:  Enzyme

Novelty:  0.08532786

p_int:  0.997762935

p_ni:  0.002063869

p_wrong:  0.000173196

Score:  0.304

Data Source:  BioPlex,STRINGDB

MFSD11

Tdark

Novelty:  0.13167358

p_int:  0.997730333

p_ni:  0.002062794

p_wrong:  0.000206872

Score:  0.199

Data Source:  BioPlex,STRINGDB

CDIPT

Tbio

Family:  Enzyme

Novelty:  0.00560887

p_int:  0.997010581

p_ni:  0.00287075

p_wrong:  0.000118669

Score:  0.216

Data Source:  BioPlex,STRINGDB

SLC5A8

Tchem

Family:  Transporter

Novelty:  0.00892277

p_int:  0.996812519

p_ni:  0.000445957

p_wrong:  0.002741524

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Endocytosis	309 targets	path:hsa04144

Name	Explore in Pharos	Explore in Source
Endocytosis	309 targets	path:hsa04144

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (2)

Components (1)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
GTPase activator activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		70.9
platelet count	EFO_0004309	1	1	1		42.3
BMI-adjusted hip circumference	EFO_0008039	1	1	1		39.6
BMI-adjusted waist circumference	EFO_0007789	1	1	1		0.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		70.9
platelet count	EFO_0004309	1		42.3
BMI-adjusted hip circumference	EFO_0008039	1		39.6
BMI-adjusted waist circumference	EFO_0007789	1		0.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
GTPase activation
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist circumference
mean platelet volume
platelet count

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	small ArfGAP2	VGNC:1554	456793
Macaque	small ArfGAP2		694502
Mouse	small ArfGAP 2	MGI:1917030	69780
Rat	small ArfGAP2	RGD:1308418	298500
Dog	small ArfGAP2	VGNC:54223	482458

Species	Name	OMA	EggNOG	Inparanoid
Chimp	small ArfGAP2
Macaque	small ArfGAP2
Mouse	small ArfGAP 2
Rat	small ArfGAP2
Dog	small ArfGAP2

Publication Statistics

PubMed Score 1.32

PubMed score by year

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PubTator Score 6.00

PubTator score by year

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Related Publications

Text Mined References (13)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title