Tbio SMAP2 Stromal membrane-associated protein 2

Protein Summary

Description

GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).

Uniprot Accession IDs

• Q8WU79
• B2R7T1
• B7Z5B5
• B7Z8V2
• D3DPV2
• Q5QPL2
• Q96C93
• Q9NST2
• Q9UJL8

Gene Name

• SMAP2

Ensembl ID

• ENST00000372708
• ENSP00000361793
• ENSG00000084070
• ENST00000372718
• ENSP00000361803
• ENST00000539317
• ENSP00000442835

Symbol

• SMAP1L
• SMAP1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.86
virus perturbation	0.76
disease perturbation	0.68
interacting protein	0.65
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.46   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.46   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0