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Tbio
SMAP2
Stromal membrane-associated protein 2

Protein Summary
Description
GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372708
  • ENSP00000361793
  • ENSG00000084070
  • ENST00000372718
  • ENSP00000361803
  • ENST00000539317
  • ENSP00000442835

Symbol
  • SMAP1L
  • SMAP1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.86
virus perturbation
0.76
disease perturbation
0.68
interacting protein
0.65
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.32   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.32   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
MFSD4A
Tdark
Novelty:  0.62186415
p_int:  0.999944602
p_ni:  0.000055379
p_wrong:  1.9e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
SLC22A12
Tclin
Family:  Transporter
Novelty:  0.00318081
p_int:  0.999937991
p_ni:  0.000061654
p_wrong:  3.55e-7
Score:  0.309
Data Source:  BioPlex,STRINGDB
CLINT1
Tbio
Novelty:  0.00945381
p_int:  0.999929334
p_ni:  0.000070481
p_wrong:  1.85e-7
Score:  0.248
Data Source:  BioPlex,STRINGDB
CELF5
Tbio
Novelty:  0.04733002
p_int:  0.999781953
p_ni:  0.000218041
p_wrong:  6e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
SLC2A4
Tchem
Family:  Transporter
Novelty:  0.00033701
p_int:  0.99969888
p_ni:  0.000287792
p_wrong:  0.000013328
Score:  0.455
Data Source:  BioPlex,STRINGDB
SLC25A11
Tbio
Family:  Transporter
Novelty:  0.06125899
p_int:  0.999523181
p_ni:  0.000476818
Score:  0.225
Data Source:  BioPlex,STRINGDB
STAMBPL1
Tbio
Family:  Enzyme
Novelty:  0.08532786
p_int:  0.997762935
p_ni:  0.002063869
p_wrong:  0.000173196
Score:  0.304
Data Source:  BioPlex,STRINGDB
MFSD11
Tdark
Novelty:  0.13167358
p_int:  0.997730333
p_ni:  0.002062794
p_wrong:  0.000206872
Score:  0.199
Data Source:  BioPlex,STRINGDB
CDIPT
Tbio
Family:  Enzyme
Novelty:  0.00560887
p_int:  0.997010581
p_ni:  0.00287075
p_wrong:  0.000118669
Score:  0.216
Data Source:  BioPlex,STRINGDB
SLC5A8
Tchem
Family:  Transporter
Novelty:  0.00892277
p_int:  0.996812519
p_ni:  0.000445957
p_wrong:  0.002741524
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
70.9
platelet count
1
1
1
42.3
BMI-adjusted hip circumference
1
1
1
39.6
BMI-adjusted waist circumference
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
70.9
platelet count
1
42.3
BMI-adjusted hip circumference
1
39.6
BMI-adjusted waist circumference
1
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small ArfGAP2
VGNC:1554
456793
Macaque
small ArfGAP2
694502
Mouse
MGI:1917030
69780
Rat
RGD:1308418
298500
Dog
small ArfGAP2
VGNC:54223
482458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small ArfGAP2
Macaque
small ArfGAP2
Mouse
Rat
Dog
small ArfGAP2
Publication Statistics
PubMed Score 1.32
PubMed score by year
PubTator Score 6.00
PubTator score by year
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Related Publications
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PMID
Year
Title