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Tbio
U2AF1L4
Splicing factor U2AF 26 kDa subunit

Protein Summary
Description
RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292879
  • ENSP00000292879
  • ENSG00000161265
  • ENST00000378975
  • ENSP00000368258
  • ENST00000412391
  • ENSP00000397645

Symbol
  • U2AF1-RS3
  • U2AF1L3
  • U2af26
  • U2AF1L3
  • U2AF1RS3
  • U2AF1-RS3
  • U2AF1L3V1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
transcription factor binding site profile
0.66
tissue sample
0.61
histone modification site profile
0.59
cell type or tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.8   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.8   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0