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Tbio
FRS2
Fibroblast growth factor receptor substrate 2

Protein Summary
Description
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397997
  • ENSP00000381083
  • ENSG00000166225
  • ENST00000549921
  • ENSP00000450048
  • ENST00000550389
  • ENSP00000447241

Symbol
  • SNT
  • SNT1
  • FRS1A
  • FRS2A
  • SNT-1
  • FRS2alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
virus perturbation
0.95
transcription factor binding site profile
0.92
biological process
0.91
microRNA
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.69   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 469   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.69   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
1
1
1
46.8
Moderate albuminuria
1
1
0
1
39.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary albumin to creatinine ratio
1
46.8
Moderate albuminuria
0
1
39.9
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (117)
Activated NTRK2 signals through FRS2 and FRS3 (R-HSA-9028731)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 63
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Axon guidance
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FRS2 and FRS3
Axon guidance
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Gene Ontology Terms (35)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (125)
1 – 10 of 125
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.998
Data Source: Reactome,STRINGDB
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
Score: 0.996
Data Source: Reactome,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.992
Data Source: Reactome,STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.99
Data Source: Reactome,STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.989
Data Source: Reactome,STRINGDB
NTRK3
Tclin
Family: Kinase
Novelty: 0.00177321
Score: 0.989
Data Source: STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
Score: 0.988
Data Source: Reactome,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.978
Data Source: STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.977
Data Source: STRINGDB
FGFR4
Tclin
Family: Kinase
Novelty: 0.00258329
Score: 0.976
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  141.69

PubMed score by year
PubTator Score  93.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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