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Tbio
RNF139
E3 ubiquitin-protein ligase RNF139

Protein Summary
Description
E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303545
  • ENSP00000304051
  • ENSG00000170881

Symbol
  • TRC8
  • RCA1
  • TRC8
  • HRCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor binding site profile
0.96
histone modification site profile
0.89
disease perturbation
0.83
tissue sample
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.16   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.16   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.9
14.2
traffic air pollution measurement
1
1
0
5.9
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.9
14.2
traffic air pollution measurement
0
5.9
14.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 139
VGNC:806
464378
Macaque
TatD DNase domain containing 1
706095
Mouse
MGI:1923091
75841
Rat
RGD:1306670
315000
Dog
ring finger protein 139
VGNC:45632
609422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 139
Macaque
TatD DNase domain containing 1
Mouse
Rat
Dog
ring finger protein 139
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WU17-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
ER Quality Control Compartment (ERQC)
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (86)
1 – 10 of 86
DERL2
Tbio
Novelty:  0.02479307
Score:  0.97
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.97
Data Source:  STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
Score:  0.968
Data Source:  STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.967
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.941
Data Source:  STRINGDB
HM13
Tbio
Family:  Enzyme
Novelty:  0.0051333
Score:  0.936
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.935
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.935
Data Source:  STRINGDB
UBE2G2
Tbio
Novelty:  0.04298958
Score:  0.933
Data Source:  STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.907
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.16

PubMed score by year
PubTator Score  20.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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