Tbio PYROXD1 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1

Protein Summary

Description

Involved in cellular response to oxidative stress. This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q8WU10
• A6NKI6
• B3KWN8
• Q9H6P1

Gene Name

• PYROXD1

Ensembl ID

• ENST00000240651
• ENSP00000240651
• ENSG00000121350
• ENST00000538582
• ENSP00000438505

Symbol

• MFM8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
histone modification site profile	0.69
cell line	0.64
microRNA	0.59
tissue	0.59

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Pyridine Nucleotide-disulfide Oxidoreductase Domain-containing Protein 1

Protein / Oxidoreductase / Oxidase / Pyridine Nucleotide-disulfide Oxidoreductase Domain-containing Protein 1

Protein / Oxidoreductase / Dehydrogenase / Pyridine Nucleotide-disulfide Oxidoreductase Domain-containing Protein 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Pyridine Nucleotide-disulfide Oxidoreductase Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.28   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.28   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0