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Tbio
NPRL2
GATOR complex protein NPRL2

Protein Summary
Description
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232501
  • ENSP00000232501
  • ENSG00000114388

Symbol
  • TUSC4
  • NPR2
  • NPR2L
  • TUSC4
  • FFEVF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
transcription factor binding site profile
0.69
histone modification site profile
0.56
tissue sample
0.55
molecular function
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.94   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.94   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
11
99.2
reticulocyte count
2
4
8
98.7
mean reticulocyte volume
1
1
1
85.1
chronotype measurement
1
1
0
1
66.8
macrophage inflammatory protein 1b measurement
1
2
2
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
11
99.2
reticulocyte count
8
98.7
mean reticulocyte volume
1
85.1
chronotype measurement
0
1
66.8
macrophage inflammatory protein 1b measurement
2
66.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NPR2 like, GATOR1 complex subunit
460393
Macaque
NPR2 like, GATOR1 complex subunit
701924
Mouse
MGI:1914482
56032
Rat
RGD:1308927
363138
Dog
NPR2 like, GATOR1 complex subunit
VGNC:43930
476614
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NPR2 like, GATOR1 complex subunit
Macaque
NPR2 like, GATOR1 complex subunit
Mouse
Rat
Dog
NPR2 like, GATOR1 complex subunit
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8WTW4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (77)
1 – 10 of 77
DEPDC5
Tbio
Novelty:  0.0177511
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NPRL3
Tbio
Family:  Enzyme
Novelty:  0.0110744
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ZBTB5
Tbio
Novelty:  0.50774653
p_int:  0.999998959
p_ni:  0.00000104
Score:  0.214
Data Source:  BioPlex,STRINGDB
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
p_int:  0.999993196
p_ni:  0.000006802
p_wrong:  2e-9
Score:  0.704
Data Source:  BioPlex,Reactome,STRINGDB
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.999887821
p_ni:  0.000112179
Score:  0.513
Data Source:  BioPlex,STRINGDB
APPBP2
Tbio
Novelty:  0.14742368
p_int:  0.971840986
p_ni:  0.028159011
p_wrong:  3e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
LRCH2
Tdark
Novelty:  1.90908316
p_int:  0.929402196
p_ni:  0.07005366
p_wrong:  0.000544144
Score:  0.188
Data Source:  BioPlex,STRINGDB
MIOS
Tdark
Novelty:  0.04252507
Score:  0.999
Data Source:  STRINGDB
WDR24
Tdark
Novelty:  0.48411996
Score:  0.999
Data Source:  STRINGDB
SEH1L
Tbio
Novelty:  0.03666501
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  41.94

PubMed score by year
PubTator Score  19.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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