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Tbio
COG1
Conserved oligomeric Golgi complex subunit 1

Protein Summary
Description
Required for normal Golgi function. The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299886
  • ENSP00000299886
  • ENSG00000166685

Symbol
  • KIAA1381
  • LDLB
  • LDLB
  • CDG2G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.87
transcription factor binding site profile
0.82
transcription factor perturbation
0.68
cell line
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
79.2
mean reticulocyte volume
1
1
1
74.6
mean corpuscular volume
1
1
1
71.9
mean corpuscular hemoglobin concentration
1
1
1
64.9
reticulocyte count
2
2
2
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
79.2
mean reticulocyte volume
1
74.6
mean corpuscular volume
1
71.9
mean corpuscular hemoglobin concentration
1
64.9
reticulocyte count
2
57.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 1
VGNC:9243
454856
Macaque
component of oligomeric golgi complex 1
695754
Mouse
MGI:1333873
16834
Rat
RGD:1304594
303652
Dog
component of oligomeric golgi complex 1
VGNC:39448
483282
Species
Name
OMA
EggNOG
Inparanoid
Chimp
component of oligomeric golgi complex 1
Macaque
component of oligomeric golgi complex 1
Mouse
Rat
Dog
component of oligomeric golgi complex 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WTW3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (191)
1 – 10 of 191
COG5
Tbio
Novelty:  0.04017657
p_int:  0.999999867
p_ni:  1.32e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG3
Tbio
Novelty:  0.02746711
p_int:  0.9999997
p_ni:  2.99e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG7
Tbio
Novelty:  0.07137701
p_int:  0.999999676
p_ni:  3.24e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG2
Tbio
Novelty:  0.03109287
p_int:  0.9999984
p_ni:  0.0000016
Score:  0.999
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999996457
p_ni:  0.000003542
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  0.999579021
p_ni:  0.000420977
p_wrong:  2e-9
Score:  0.607
Data Source:  BioPlex,STRINGDB
BIN3
Tbio
Novelty:  0.02034119
p_int:  0.996342232
p_ni:  0.003657768
Score:  0.167
Data Source:  BioPlex,STRINGDB
CD274
Tclin
Novelty:  0.00013449
p_int:  0.9960942
p_ni:  0.0039058
Score:  0.669
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.982372891
p_ni:  0.017627108
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.980366386
p_ni:  0.019633614
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  82.65

PubMed score by year
PubTator Score  41.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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