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Tdark
THAP3
THAP domain-containing protein 3

Protein Summary
Description
Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000054650
  • ENSP00000054650
  • ENSG00000041988
  • ENST00000307896
  • ENSP00000311537
  • ENST00000377627
  • ENSP00000366854
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
tissue sample
0.63
histone modification site profile
0.6
microRNA
0.57
transcription factor
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
86
Protein-Protein Interactions (79)
1 – 10 of 79
HIST1H1T
Tdark
Novelty: 0.01039464
p_int: 0.99999296
p_ni: 0.000007031
p_wrong: 9e-9
Data Source: BioPlex
GOLGA2
Tbio
Novelty: 0.00544771
p_int: 0.999951309
p_ni: 0.00004869
Data Source: BioPlex
ZNF70
Tdark
Family: TF
Novelty: 0.51405169
p_int: 0.999323066
p_ni: 0.000676887
p_wrong: 4.7e-8
Data Source: BioPlex
HCFC1
Tbio
Novelty: 0.00440762
p_int: 0.99931263
p_ni: 0.00068737
Score: 0.752
Data Source: BioPlex,STRINGDB
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999277734
p_ni: 9e-7
p_wrong: 0.000721366
Score: 0.248
Data Source: BioPlex,STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
p_int: 0.998526782
p_ni: 0.001473202
p_wrong: 1.6e-8
Data Source: BioPlex
GTF2H4
Tbio
Novelty: 0.03140561
p_int: 0.997918717
p_ni: 0.00208084
p_wrong: 4.43e-7
Data Source: BioPlex
ZNF16
Tbio
Family: TF
Novelty: 0.18433365
p_int: 0.993099974
p_ni: 0.006881942
p_wrong: 0.000018084
Data Source: BioPlex
THAP11
Tbio
Family: TF
Novelty: 0.0679686
p_int: 0.992930506
p_ni: 0.007054594
p_wrong: 0.000014901
Score: 0.811
Data Source: BioPlex,STRINGDB
OSBPL3
Tbio
Novelty: 0.06106368
p_int: 0.989247531
p_ni: 0.010752469
Data Source: BioPlex
Publication Statistics
PubMed Score  2.07

PubMed score by year
PubTator Score  0.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer