Tchem SCARB1 Scavenger receptor class B member 1

Protein Summary

Description

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218). (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694). The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2019]

Uniprot Accession IDs

• Q8WTV0
• F8W8N0
• Q14016
• Q52LZ5
• Q6KFX4
• SRB1

Gene Name

• SCARB1

Ensembl ID

• ENST00000261693
• ENSP00000261693
• ENSG00000073060
• ENST00000339570
• ENSP00000343795
• ENST00000415380
• ENSP00000414979

Symbol

• CD36L1
• CLA1
• CLA1
• SRB1
• CLA-1
• SR-BI
• CD36L1
• HDLQTL6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
cellular component	0.99
biological term	0.98
molecular function	0.96
disease	0.94

Protein Classes

PANTHER Classes

Protein / Receptor / Scavenger Receptor Class B Member 1

DTO Classes

Protein / Receptor / Scavenger Receptor Class B Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2801.27   (req: < 5)

Gene RIFs: 242   (req: <= 3)

Antibodies: 536   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2801.27   (req: >= 5)

Gene RIFs: 242   (req: > 3)

Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0