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Tchem
SCARB1
Scavenger receptor class B member 1

Protein Summary
Description
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218). (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694). The protein encoded ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261693
  • ENSP00000261693
  • ENSG00000073060
  • ENST00000339570
  • ENSP00000343795
  • ENST00000415380
  • ENSP00000414979

Symbol
  • CD36L1
  • CLA1
  • CLA1
  • SRB1
  • CLA-1
  • SR-BI
  • CD36L1
  • HDLQTL6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
cellular component
0.99
biological term
0.98
molecular function
0.96
disease
0.94


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2801.27   (req: < 5)
Gene RIFs: 242   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2801.27   (req: >= 5)
Gene RIFs: 242   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0