Tchem SCARB1 Scavenger receptor class B member 1

Protein Classes

PANTHER Classes

Protein / Receptor / Scavenger Receptor Class B Member 1

DTO Classes

Protein / Receptor / Scavenger Receptor Class B Member 1

Protein Summary

Description

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218). (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694). The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2019]

Uniprot Accession IDs

• Q8WTV0
• F8W8N0
• Q14016
• Q52LZ5
• Q6KFX4
• SRB1

Gene Name

• SCARB1

Ensembl ID

• ENST00000261693
• ENSP00000261693
• ENSG00000073060
• ENST00000339570
• ENSP00000343795
• ENST00000415380
• ENSP00000414979

Symbol

• CD36L1
• CLA1
• CLA1
• SRB1
• CLA-1
• SR-BI
• CD36L1
• HDLQTL6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
cellular component	0.99
biological term	0.98
molecular function	0.96
disease	0.94

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1221.45   (req: < 5)

Gene RIFs: 242   (req: <= 3)

Antibodies: 536   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1221.45   (req: >= 5)

Gene RIFs: 242   (req: > 3)

Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 51

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (51)

Explore Active Ligands

1 – 10 of 51

CHEMBL3787277

SCARB1Tchem

IC50 : 6

CHEMBL3786485

SCARB1Tchem

IC50 : 6

CHEMBL3786591

SCARB1Tchem

IC50 : 6

CHEMBL1914863

SCARB1Tchem

IC50 : 6.2

CHEMBL1914862

SCARB1Tchem

IC50 : 6.22

CHEMBL2179491

SCARB1Tchem

IC50 : 6.3

CHEMBL3787449

SCARB1Tchem

IC50 : 6.3

CHEMBL1914861

SCARB1Tchem

IC50 : 6.64

CHEMBL3785530

SCARB1Tchem

IC50 : 6.7

CHEMBL3786659

SCARB1Tchem

IC50 : 6.8

GWAS Traits (24)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 24

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	12	16	26		98
coronary artery disease	EFO_0001645	6	4	5	2.4	88.5
low density lipoprotein cholesterol measurement	EFO_0004611	3	3	3		86.2
lipoprotein-associated phospholipase A(2) measurement	EFO_0004746	3	3	1	4.1	86.1
renal cell carcinoma	EFO_0000681	2	1	0	1.1	79.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	26		98
coronary artery disease	EFO_0001645	5	2.4	88.5
low density lipoprotein cholesterol measurement	EFO_0004611	3		86.2
lipoprotein-associated phospholipase A(2) measurement	EFO_0004746	1	4.1	86.1
renal cell carcinoma	EFO_0000681	0	1.1	79.8

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	scavenger receptor class B member 1	VGNC:8529	452359
Macaque	scavenger receptor class B member 1		712726
Mouse	scavenger receptor class B, member 1	MGI:893578	20778
Rat	scavenger receptor class B, member 1	RGD:2302	25073
Dog	scavenger receptor class B member 1	VGNC:45898	486241

Species	Name	OMA	EggNOG	Inparanoid
Chimp	scavenger receptor class B member 1
Macaque	scavenger receptor class B member 1
Mouse	scavenger receptor class B, member 1
Rat	scavenger receptor class B, member 1
Dog	scavenger receptor class B member 1

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q8WTV0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (31)

Reactome (7)

KEGG (10)

WikiPathways (14)

Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Reactome	HDL clearance	5 targets	R-HSA-8964011
Reactome	Plasma lipoprotein assembly, remodeling, and clearance	71 targets	R-HSA-174824
Reactome	Plasma lipoprotein clearance	33 targets	R-HSA-8964043
Reactome	Scavenging by Class B Receptors	6 targets	R-HSA-3000471

Name	Explore in Pharos	Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
HDL clearance	5 targets	R-HSA-8964011
Plasma lipoprotein assembly, remodeling, and clearance	71 targets	R-HSA-174824
Plasma lipoprotein clearance	33 targets	R-HSA-8964043
Scavenging by Class B Receptors	6 targets	R-HSA-3000471

Gene Ontology Terms (50)

Functions (14)

Components (9)

Processes (27)

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Items per page:

10

1 – 10 of 14

GO Term	Evidence	Assigned by
high-density lipoprotein particle receptor activity	Inferred from Direct Assay (IDA)	BHF-UCL
lipopolysaccharide binding	Inferred from Direct Assay (IDA)	BHF-UCL
lipopolysaccharide receptor activity	Inferred from Direct Assay (IDA)	BHF-UCL
low-density lipoprotein particle binding	Inferred from Direct Assay (IDA)	BHF-UCL
apolipoprotein A-I binding	Inferred from Physical Interaction (IPI)	BHF-UCL
apolipoprotein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
phosphatidylserine binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
1-phosphatidylinositol binding	Traceable Author Statement (TAS)	BHF-UCL
scavenger receptor activity	Traceable Author Statement (TAS)	ARUK-UCL
transporter activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (148)

Explore Interacting Targets

1 – 10 of 148

• See Interactions on String-DB

BTNL8

Tdark

Novelty: 0.40339869

p_int: 0.998929543

p_ni: 0.001070457

Data Source: BioPlex

PDZK1P1

Tdark

p_int: 0.995777159

p_ni: 0.004222841

Data Source: BioPlex

TMEM30B

Tbio

Novelty: 0.26735006

p_int: 0.994717173

p_ni: 0.005282825

p_wrong: 2e-9

Data Source: BioPlex

HLA-DRA

Tbio

Novelty: 0.0060214

p_int: 0.979711363

p_ni: 0.020288637

Score: 0.158

Data Source: BioPlex,STRINGDB

CLDN7

Tbio

Novelty: 0.00722366

p_int: 0.972977433

p_ni: 0.027022567

Score: 0.714

Data Source: BioPlex,STRINGDB

PTPRK

Tbio

Family: Enzyme

Novelty: 0.03149943

p_int: 0.96798853

p_ni: 0.03201147

Data Source: BioPlex

SFTPC

Tbio

Novelty: 0.00154396

p_int: 0.967174807

p_ni: 0.032825193

Score: 0.197

Data Source: BioPlex,STRINGDB

EDDM3A

Tdark

Novelty: 0.05607223

p_int: 0.943423891

p_ni: 0.056576109

Data Source: BioPlex

PON2

Tbio

Family: Enzyme

Novelty: 0.00414855

p_int: 0.911801087

p_ni: 0.088198905

p_wrong: 8e-9

Score: 0.266

Data Source: BioPlex,STRINGDB

KDELR2

Tbio

Novelty: 0.12002642

p_int: 0.908616639

p_ni: 0.091383361

Data Source: BioPlex

Publication Statistics

PubMed Score  1221.45

PubMed score by year

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PubTator Score  581.53

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Lipoprotein
Membrane
Palmitate

GWAS Trait Find Similar Targets

acute coronary syndrome
alcohol drinking
apolipoprotein A 1 measurement
apolipoprotein B measurement
bilirubin measurement
blood metabolite measurement
BMI-adjusted waist-hip ratio
C-reactive protein measurement
coronary artery disease
high density lipoprotein cholesterol measurement

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging